Remote Ischaemic Preconditioning for Heart Surgery (RIPHeart-Study)

Status Terminated

Clinical Trial Summary

The purpose of this study is to evaluate the effects of Remote Ischaemic Preconditioning on perioperative ischaemic injury in patients undergoing cardiac surgery compared to control intervention.

Clinical Trial Description

Cardiac surgery with cardiopulmonary bypass is associated with a predictable incidence of myocardial, neurological and renal dysfunction. This significant morbidity and mortality is at least partly due to perioperative ischaemia. Remote ischaemic preconditioning (RIPC) is a novel, simple, non-invasive and inexpensive intervention by which ischaemia of non-vital tissue (skeletal muscles) protects remote organs (heart, brain and kidney) from a subsequent sustained episode of ischaemia. The investigators perform a multicenter randomized controlled study to evaluate that RIPC reduces teh severity of perioperative ischaemic injury in patients undergoing cardiac surgery, and results in about 1/3 risk reduction in the occurence of major adverse events. ;

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01067703
Study type	Interventional
Source	University of Schleswig-Holstein
Contact
Status	Terminated
Phase	Phase 3
Start date	December 2010
Completion date	May 2015

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04507867` - Effect of a NSS to Reduce Complications in Patients With Covid-19 and Comorbidities in Stage III	N/A
Completed	`NCT04092465` - Outcomes of Surgical Resection After Induction Treatment in Non-Small Cell Lung Cancer (SRaIT)
Completed	`NCT03296423` - Bacillus Calmette-guérin Vaccination to Prevent Infections of the Elderly	Phase 4
Not yet recruiting	`NCT04900610` - The Effect of Vitamin K2 Supplementation on Arterial Stifness and Cardiovascular Events in PEritonial DIAlysis	N/A
Completed	`NCT04149873` - Effectness of Treatment With Mechanical Insufflation-Exsufflation	N/A
Completed	`NCT05905042` - Follow-up of Recovery Condition in Survivors of Acute Respiratory Distress Syndrome
Completed	`NCT00527774` - Effect of HCV Infection on Insulin Resistance and Malnutrition-inflammation Complex Syndrome in Regular Hemodialysis Patients	N/A
Completed	`NCT00518856` - Lufwanyama Neonatal Survival Project	N/A
Completed	`NCT06051526` - The African Critical Illness Outcomes Study
Recruiting	`NCT05055089` - Short- and Medium-term Results of New Generation Aortic
Active, not recruiting	`NCT04132492` - AGNES - Aging Nephropathy Study, a Prospective Observational Cohort of Chronic Kidney Disease in Elderly Patients
Completed	`NCT03885206` - Effectiveness and Clinical Outcomes of Municipal Acute Wards Versus a General Hospital	N/A
Completed	`NCT05573659` - Capillary Refill Time Calculated With a Video-assisted Method Has a Better Reproducibility Than Visual Method in Critically Ill Patients	N/A
Withdrawn	`NCT03245658` - The Effect of Cannabis in Pancreatic Cancer	Phase 2
Recruiting	`NCT04094428` - Burden, Mortality and Supply Costs in Intensive Care Unit Patients
Completed	`NCT01631799` - Outcome of Patients After Total Knee Replacement: A Comparison of Femoral Nerve Block and Epidural Anesthesia	N/A
Completed	`NCT00244673` - Randomized Study of Not Giving Diphteria-tetanus-pertussis Vaccination With or After Measles Vaccination	Phase 4
Completed	`NCT03378843` - Spermidine Intake and All-cause Mortality	N/A
Recruiting	`NCT04424511` - Effects of Mass Drug Administration of Azithromycin on Mortality and Other Outcomes Among 1-11 Month Old Infants in Mali	Phase 3
Completed	`NCT04032288` - Establish a Prospective Registration System of ARDS Patients for Improving Quality of Care