A Comparative Study of Using Scorpion Antivenom Versus Scorpion Antivenom

Status Recruiting

Clinical Trial Summary

Interventional study designed for the evaluation of characters and the outcome of scorpion sting patients will admit to Sohag University Hospitals in 2 randomized groups. The first group will receive scorpion antivenom only whether by the intravenous or the intramuscular route of administration. The second group will receive a combination of prazosin plus scorpion antivenom whether by the intravenous or the intramuscular route of administration. Both groups will receive proper first aid and supportive treatment

Clinical Trial Description

Tools of the study: 1. Dose and administration of prazosin: 30 μg/kg/dose of prazosin will be delivered orally every 6 hours 4 doses, in adults we shouldn't exceed 1 mg per dose. Prazosin will be delivered using a nasogastric tube while securing the patient's airway in the event of vomiting or unconsciousness. Every 30 minutes for the first three hours, every hour for the following six, and then every four hours until improvement, blood pressure, pulse rate, respiration rate, and oxygen saturation will be measured. When pain is the only symptom, prophylaxis shouldn't be given. To avoid the first-dose phenomenon, the patient should remain in a laying position for around 3 hours (even while the case is being examined) (Shoreit et al., 2019). Dose of antivenom 1-1 ampoule intramuscular and/ or, 2-1 to 5 Polyvalent anti-scorpion serum ampoules produced by the vaccine & serum institution (VACSERA)in Egypt according to the severity of the case on 200 to 500 ml glucose 5% infusion and assess the patient clinically to repeat the dose after 4 to 6 hours. (Shoreit et al., 2019) 2. A prepared sheet containing 1. the demographic characteristics of each patient 2. Vital signs and degree of coma at time of admission of the patient. 3. First aid management as resuscitation. 4. Supportive management will be done to the patients during the admission will be recorded. 5. Cardiac enzymes measurements, duration of hospital stay and the outcome of patients in each group. ;

Study Design

Related Conditions & MeSH terms

Morality

Clinical Trial Details

NCT number	NCT06287905
Study type	Interventional
Source	Sohag University
Contact	Meray M Shokry Zaghary, PhD
Phone	+201028911003
Email	drevanho2013@gmail.com
Status	Recruiting
Phase	Phase 4
Start date	February 1, 2023
Completion date	July 1, 2024

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Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

A Comparative Study of Using Scorpion Antivenom Versus Scorpion Antivenom and Prazosin

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms