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Clinical Trial Summary

The detection of antiphospholipid antibodies (aPL) is of interest because of their importance in the pathogenesis of arterial or venous thrombosis and their responsibility for a wide spectrum of clinical manifestations such as infection. The aim of the study was to assess the performance of antiphospholipid antibodies biomarker to predict in- hospital mortality in intensive care unit (ICU) septic patient's.


Clinical Trial Description

the investigators conducted a prospective single-center observational study including consecutive critically ill septic adults admitted to the intensive care unit. Clinical and laboratory data including chemiluminescence immunoassay for antiphospholipid antibodies [anticardiolipin (aCL), antiphosphatidylserine (aPS)] were obtained. Blood samples were collected on days 1, 3, 5, 8 and 10 of hospitalization. The primary study endpoint was ICU mortality defined as death before ICU discharge. Secondary end points included correlation between SOFA score and biological parameters. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04685278
Study type Observational
Source Military Hospital of Tunis
Contact Zied Hajjej, Pr
Phone 0021620358907
Email hajjej_zied@hotmail.com
Status Recruiting
Phase
Start date October 1, 2020
Completion date February 15, 2021

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