Incretin Regulation of Insulin Secretion in Monogenic Diabetes

Monogenic Diabetes Clinical Trial

Official title: Incretin Regulation of Insulin Secretion in Monogenic Diabetes

Status Completed

Clinical Trial Summary

The purpose of this study is to explore the mechanisms of metabolic control in monogenic diabetes patients treated with sulfonylurea medications.

Clinical Trial Description

Monogenic diabetes patients and healthy matched controls will be admitted to the University of Chicago Clinical Resource Center for a total of 4 nights. The following will take place on separate days:

1. Oral Glucose Tolerance Test (OGTT): consume sugary drink and blood samples will be collected at multiple time points

2. Isoglycemic glucose infusion (IGI) test: glucose will be infused via a vein in the arm and and blood samples will be collected at multiple time points

3. OGTT during GLP-1 infusion

4. IGI during Exendin-9 infusion ;

Related Conditions & MeSH terms

• Diabetes Mellitus
• Monogenic Diabetes

• NCT number: NCT01795144
• Study type: Interventional
• Source: University of Chicago
• Status: Completed
• Phase: Phase 1
• Start date: January 2014
• Completion date: March 2017