Monoclonal Gammopathy of Unknown Significance Clinical Trial
Official title:
Understanding Monoclonal Gammopathy of Unknown Significance (MGUS): A Research Study to Investigate the Functional Consequences of Paraprotein Production in MGUS
This is a study to investigate the functional consequences of paraprotein production in MGUS (Monoclonal Gammopathy of Unknown Significance).
Monoclonal gammopathy of unknown significance (MGUS) is a common haematological condition. It
is characterised by proliferation of a B lymphocyte clone and it's associated antibody
(paraprotein). In most cases there are no clinical symptoms, however, in a small number of
individuals there may be an interaction of the paraprotein with a molecule expressed by the
body (self antigen). This can have effects on the normal function of this molecule and/or
cause disease.
The study aims to investigate the functional consequences of paraprotein production in MGUS.
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