Colonoscopy Clinical Trial
Official title:
GABA Antagonist to Improve Reversal of Anesthesia: a Double Blind Study With High-density EEG Surveillance
For recent years, patients are more likely to accept sedation during endoscopic examination
due to better quality and experience. Modest anesthetic state for different kind of procedure
is important, but it is also not easy to maintain in the same state all the time. Thus, to
prevent awareness during the procedure, monitoring the brain state is an important issue.
Traditionally, anesthesiologists assess patients' brain state from heart rate, blood pressure
and muscle tone. All these vital signs are indirect hint for the real brain state. Thus,
electroencephalogram(EEG) was considered to be potential tool to directly monitor our brain
during anesthesia. In 1937, EEG study was started in anesthetic patients. Until 1994,
Bispectral Index, the first commercialized processed EEG monitor, was published for
intra-operative brain state assessment. To perform EEG study on a surgical patient is not
easy due to the complex circuits and lots of interrupts during the procedure. This might be
the reason why most of the EEG studies under anesthesia are collecting from healthy
volunteers. It takes longer preparation, better team cooperation, and support from hospital
to start this study in endoscopy room.
The investigators would like to start from a preliminary study, 5 patients in each groups,
and collect the EEG during peri-endoscopic period. The sedation steps follow the routine
protocol of our practice. Flumazenil and placebo are given to the groups separately on the
end of the examination. From this study, further understanding of human brain during sedation
especially in such short periods is expected. And furthermore, to give safer and more
comfortable anesthetic experience for the patients.
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