Colonoscopy Clinical Trial
Official title:
GABA Antagonist to Improve Reversal of Anesthesia: a Double Blind Study With High-density EEG Surveillance
For recent years, patients are more likely to accept sedation during endoscopic examination
due to better quality and experience. Modest anesthetic state for different kind of procedure
is important, but it is also not easy to maintain in the same state all the time. Thus, to
prevent awareness during the procedure, monitoring the brain state is an important issue.
Traditionally, anesthesiologists assess patients' brain state from heart rate, blood pressure
and muscle tone. All these vital signs are indirect hint for the real brain state. Thus,
electroencephalogram(EEG) was considered to be potential tool to directly monitor our brain
during anesthesia. In 1937, EEG study was started in anesthetic patients. Until 1994,
Bispectral Index, the first commercialized processed EEG monitor, was published for
intra-operative brain state assessment. To perform EEG study on a surgical patient is not
easy due to the complex circuits and lots of interrupts during the procedure. This might be
the reason why most of the EEG studies under anesthesia are collecting from healthy
volunteers. It takes longer preparation, better team cooperation, and support from hospital
to start this study in endoscopy room.
The investigators would like to start from a preliminary study, 5 patients in each groups,
and collect the EEG during peri-endoscopic period. The sedation steps follow the routine
protocol of our practice. Flumazenil and placebo are given to the groups separately on the
end of the examination. From this study, further understanding of human brain during sedation
especially in such short periods is expected. And furthermore, to give safer and more
comfortable anesthetic experience for the patients.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04101097 -
Training and Validation of Models of Factors to Predict Inadequate Bowel Preparation Colonoscopy
|
||
| Completed |
NCT03247595 -
Testing How Well Magnesium Citrate Capsules Work as Preparation for a Colonoscopy
|
N/A | |
| Completed |
NCT04214301 -
An Open-Label Preference Evaluation of BLI800
|
Phase 4 | |
| Withdrawn |
NCT05754255 -
Comparison of High-flow Oxygen With or Without Nasal Positive Airway Pressure (PAP) During Propofol Sedation for Colonoscopy in an Ambulatory Surgical Center
|
N/A | |
| Recruiting |
NCT02484105 -
Comforting Conversation During Colonoscopy: A Trial on Patient Satisfaction
|
Phase 4 | |
| Active, not recruiting |
NCT02264249 -
Residual Gastric Volume in Same Day Versus Split Dose and Evening Before Bowel Preparation
|
N/A | |
| Terminated |
NCT01978509 -
The Affect of Low-Volume Bowel Preparation for Hospitalized Patients Colonoscopies
|
N/A | |
| Completed |
NCT01964417 -
The Comparative Study Between Bowel Preparation Method
|
Phase 3 | |
| Recruiting |
NCT01685970 -
Comparison of Same-day 2 Sachets Picosulfate Versus High Volume PEG for Afternoon Colonoscopy
|
Phase 3 | |
| Completed |
NCT01518790 -
Short Course, Single-dose PEG 3350 for Colonoscopy Prep in Children
|
N/A | |
| Recruiting |
NCT00748293 -
Achievement of Better Examinee Compliance on Colon Cleansing Using Commercialized Low-Residue Diet
|
N/A | |
| Completed |
NCT00779649 -
MoviPrep® Versus HalfLytely®, Low-VolUme PEG Solutions for Colon Cleansing: An InvesTigator-blindEd, Randomized, Trial
|
Phase 4 | |
| Completed |
NCT00671177 -
Clinical Evaluation of Water Immersion Colonoscopy Insertion Technique
|
N/A | |
| Completed |
NCT00380497 -
Pico-Salax Versus Poly-Ethylene Glycol for Bowel Cleanout Before Colonoscopy in Children
|
Phase 4 | |
| Recruiting |
NCT00160823 -
Impact of a Self-Administered Information Leaflet on Adequacy of Colonic Cleansing for in-Hospital Patients
|
Phase 3 | |
| Completed |
NCT00314418 -
Patient Position and Impact on Colonoscopy Time
|
N/A | |
| Completed |
NCT00390598 -
PEG Solution (Laxabon®) 4L Versus Senna Glycoside (Pursennid® Ex-Lax) 36mg and PEG Solution (Laxabon®) 2L for Large Bowel Cleansing Prior to Colonoscopy
|
Phase 2/Phase 3 | |
| Completed |
NCT00427089 -
Comparison of 2L NRL994 With NaP Preparation in Colon Cleansing Prior to Colonoscopies for Colon Tumor Screening
|
Phase 3 | |
| Completed |
NCT00209573 -
A Study of AQUAVAN® Injection Versus Midazolam HCl for Sedation in Patients Undergoing Elective Colonoscopy
|
Phase 3 | |
| Completed |
NCT05823350 -
The Effect of Abdominal Massage on Pain and Distention After Colonoscopy
|
N/A |