Atrial Fibrillation Clinical Trial
Official title:
Efficacy and Safety of Rivaroxiban Compare With Vitamin K Antagonist Warfarin in Patients With Atrial Fibrillation and Mitral Stenosis Among Pakistani Population
Title: Efficacy and safety of rivaroxiban compare with vitamin K antagonist warfarin in patients with atrial fibrillation and mitral stenosis among Pakistani population.
Atrial fibrillation is associated with an increase in the risk of ischemic stroke by a factor
of four to five and accounts for up to 15% of strokes in persons of all ages and 30% in
persons over the age of 80 years. The use of vitamin K antagonists is highly effective for
stroke prevention in patients with non-valvular atrial fibrillation and is recommended for
persons at increased risk. However, food and drug interactions necessitate frequent
coagulation monitoring and dose adjustments, requirements that make it difficult for many
patients to use such drugs in clinical practice.
Rivaroxaban is a direct factor Xa inhibitor that may provide more consistent and predictable
anticoagulation than warfarin. It has been reported to prevent venous thromboembolism more
effectively than enoxaparin in patients undergoing orthopedic surgery and was non-inferior to
enoxaparin followed by warfarin in a study involving patients with established venous
thrombosis. This trial was designed to compare once-daily oral rivaroxaban with dose-adjusted
warfarin for the prevention of stroke and systemic embolism in patients with nonvalvular
atrial fibrillation who were at moderate-to-high risk for stroke
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