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Mitral Valve Replacement clinical trials

View clinical trials related to Mitral Valve Replacement.

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NCT ID: NCT05838846 Active, not recruiting - Clinical trials for Pulmonary Hypertension

Inhaled Versus Intravenous Milrinone for Patients Undergoing Mitral Valve Replacement Surgery

Start date: April 1, 2023
Phase: Phase 2/Phase 3
Study type: Interventional

This prospective double blinded randomized study aims to compare the effect of inhaled versus intravenous milrinone on the pulmonary vascular resistance in patients undergoing mitral valve replacement surgery. The primary outcome is to determine change in pulmonary artery pressure. The secondary outcomes include, - Incidence of systemic hypotension. - Hemodynamic affection and need of vasopressors and inotropes. - Change in pulmonary vascular resistance versus systemic vascular resistance. - Right ventricular function. - Duration of mechanical ventilation. - Need for mechanical circulatory support devices. - Urine output - Length of intensive care (ICU) in stay. As the investigators hypothesize that inhaled milrinone has a selective pulmonary vasodilator effect devoid of the systemic hypotension with the intravenous administration.

NCT ID: NCT05438433 Completed - Clinical trials for Mitral Valve Replacement

Outcome of Preserved Mitral Valve Apparatus During Mitral Valve Replacement

EarlyOutcome
Start date: December 28, 2016
Phase: N/A
Study type: Interventional

Are there differences in outcome of mitral valve replacement with preservation of mitral apparatus among rheumatic and/or ischemic mitral lesions?. Mitral valve replacement with preservation of leaflets, and added coronary artery-bypass surgery, when indicated, is it a feasible and reproducible procedure?. The study was designed to compare outcome after prosthetic mitral replacement with preservation of mitral apparatus for rheumatic valve disease with outcome of replacement for ischemic myocardium and mitral valve disease, The outcomes will be guided by clinical assessment. and echo-cardiograph.

NCT ID: NCT03885570 Recruiting - Clinical trials for Blood Transfusion Complication

Blood Transfusion Management in Patients With Mitral Valve Replacement in China

Start date: September 16, 2019
Phase:
Study type: Observational

The evaluation uses ΔHb as an independent factor combined with artificial intelligence (AI) to predict its impact on the prognosis and blood transfusion of patients undergoing cardiac surgery, thereby guiding perioperative clinical blood use and improving patient prognosis.

NCT ID: NCT02097420 Completed - Clinical trials for Mitral Valve Disease

HALO: A Single Arm Prospective Investigation of the SJM™ Masters HP™ 15mm Rotatable Mechanical Heart Valve

Start date: May 7, 2015
Phase: N/A
Study type: Interventional

The purpose of the study is to provide evidence of safety and effectiveness of the study valve. The rationale is to offer a replacement mitral valve for patients with anatomy that is too small for the currently commercially available valves ranging in size from 16mm to 37mm. 20 subjects were enrolled as part of the IDE cohort and an additional 3 were enrolled under continued access.