Clinical Trials Logo

Mitral Valve Disease clinical trials

View clinical trials related to Mitral Valve Disease.

Filter by:

NCT ID: NCT03444259 Active, not recruiting - Clinical trials for Coronary Artery Disease

Prospective Project to Identify Biomarkers of Morbidity and Mortality in Cardiovascular Interventional Patients

CAREBANK
Start date: February 1, 2016
Phase:
Study type: Observational [Patient Registry]

The objective of CAREBANK study is to establish definitive relationships with human cardiac samples and clinical phenotypes in patients undergoing cardiac procedures. Specifically, the investigators aim at comparing atrial phenotypes from atrial fibrillation patients and controls. The work consists of three broad categories: A) role of atrial cardiomyopathy in atrial fibrillation; B) genetic defects predisposing to atrial fibrillation; and C) the role of inflammation in atrial fibrillation.

NCT ID: NCT03438825 Completed - Clinical trials for Mitral Valve Disease

PRediction of Early PostoperAtive Right vEntricular Failure in Mitral Valve Replacement/Repair Patients

PREPARE-MVR
Start date: October 2016
Phase:
Study type: Observational

The PREPARE-MVR (PRediction of Early PostoperAtive Right vEntricular failure in Mitral Valve Replacement/Repair patients) Study aims to evaluate those preoperative factors which can predict the early postoperative right ventricular failure or determine the functional shift seen in right ventricular function after mitral valve replacement/repair. The PREPARE-MVR study focuses mainly on echocardiographic (both conventional and advanced) parameters and includes right heart catheterization intraoperatively and in the early postoperative period as gold standard method.

NCT ID: NCT03415555 Completed - Postoperative Pain Clinical Trials

Postoperative Analgesia After Minithoracotomy

Start date: February 7, 2018
Phase: Phase 4
Study type: Interventional

Patients scheduled for minimally invasive mitral valve replacement. Each patient will be treated with intravenous (i.v.) oxycodone - patient-controlled analgesia (PCA). Half of the patients will be randomly allocated to Erector Spinae Plane (ESP) blockade group.

NCT ID: NCT03366649 Completed - Clinical trials for Coronary Artery Disease

Improving Mitral Repair for Functional Mitral Regurgitation

IMPROVE-FMR
Start date: March 20, 2018
Phase: N/A
Study type: Interventional

The investigators are interested in determining the best surgical technique to correct functional mitral regurgitation, as there is currently not one technique that is established to work better than the other. The technique used in current clinical practice is undersizing mitral annuloplasty (UMA), in which a prosthetic ring is implanted onto the mitral valve to correct the leakage. Though widely adopted, durability of the repair is less, as 58% of the patients present with recurrent FMR within 2 years. There are no specific algorithms to predict who might have UMA failure, but research indicates that some geometric indices might be strong predictors. The investigators are interested in testing the hypothesis that, elevated lateral inter-papillary muscle separation (IPMS) is a predictor of post-UMA recurrence of FMR at 12 months. In the first part of this study, the study team will measure lateral IPMS before surgery, and relate to post-surgery FMR severity at discharge/30 days, 6 months and 12 months. A relatively newer technique is papillary muscle approximation (PMA), in which a suture draws together the two muscles that connect the mitral valve to the heart muscle prior to performing UMA. This reduces the lateral inter-papillary muscle separation (IPMS) and is expected to improve the durability of UMA. In the second part of this study, the investigators will perform PMA and UMA together and determine if FMR severity is reduced at discharge/30 days, 6 months and 12 months.

NCT ID: NCT03365453 Active, not recruiting - Clinical trials for Aortic Valve Disease

Frailty in Elderly Patients Receiving Surgical or Percutaneous Procedures for Valvular Disorders

FRASER-VD
Start date: December 1, 2017
Phase: N/A
Study type: Interventional

In Italy, life expectancy at birth has reached 80 years in men and 85 in women; in about 50 years, life expectancy at the age of 80 has increased by an extraordinary 61% and 55%, respectively, due to more effective therapies and lower mortality of many diseases. Yet, chronic diseases are nowadays more important, and often coexist as comorbidity or multimorbidity, depending on whether an index condition has been considered. These conditions increase the risk of death and reduce functional autonomy in the elderly and, therefore, should be carefully considered within comprehensive geriatric assessment. The epidemiology of valvular disease shows a clear trend in age-dependent, as the number of events and their incidence increases with age, and about half are concentrates over 75 years. In addition, some observational studies in elderly patients have suggested an association between frailty and cardiovascular disease: fragility and cardiovascular disease share a common biological pathway, and cardiovascular diseases may accelerate the onset of frailty. The frailty syndrome was identified in 25% to 50% of patients with cardiovascular disease, according to the rating scale used and the population studied. Frail patients with cardiovascular disease, in particular those undergoing invasive procedures or suffering from coronary artery disease and aortic valve disease, have a much higher adverse events and complications, suggesting the need for a more accurate functional stratification and a more careful evaluation of the risk/benefit ratio of some invasive procedures. Among the numerous tests proposed in the literature for the functional evaluation and objective measures of physical capability in elderly patient, the Short Physical Performance Battery (SPPB) and the evaluation of hand grip strength (grip strength) are those characterized by an improved prognostic ability and an easy administration. The present study is performed to assess if SPPB and handgrip are helpful to better stratify the prognosis (all-causes death and hospital admission for all causes) in elderly patients admitted to hospital for cardiac causes.

NCT ID: NCT03339115 Recruiting - Clinical trials for Mitral Regurgitation

AHEAD: European Feasibility Study of the Cardiovalve Transfemoral Mitral Valve System

AHEAD
Start date: April 23, 2018
Phase: N/A
Study type: Interventional

This study will evaluate the safety of the Cardiovalve Transfemoral Mitral Valve System with its associated procedure, and observe the device performance in reducing mitral regurgitation. Data collected in this clinical study will include 30-day safety and performance, and long-term clinical outcomes over a follow-up of 2 years.

NCT ID: NCT03283722 Completed - Clinical trials for Mitral Valve Disease

PRESERVE-MITRAL Post-Market Registry

Start date: September 22, 2017
Phase:
Study type: Observational

The objective of this registry is to gather data on the clinical outcomes of Medtronic mitral repair products (Profile 3Dâ„¢ and CG Future® annuloplasty systems) in the approved intended use up to 12 months from the day of procedure

NCT ID: NCT03239262 Completed - Clinical trials for Coronary Artery Disease

Left Atrial Cryoablation Enhanced by Ganglionated Plexi Ablation in the Treatment of Atrial Fibrillation

Start date: July 1, 2012
Phase: N/A
Study type: Interventional

The aim of our study was to investigate, whether enhancement of left atrial cryoablation by ablation of the autonomic nervous system of left atrium leads to influencing the outcomes of surgical treatment of atrial fibrillation in patients with structural heart disease undergoing open-heart surgery.

NCT ID: NCT03223558 Completed - Clinical trials for Coronary Artery Disease

Early Initiation of Post Sternotomy CArdiac Rehabilitation

SCAR
Start date: July 10, 2017
Phase: N/A
Study type: Interventional

The main objective of this trial is to investigate the effects of starting exercise rehabilitation earlier than current practice after coronary artery bypass graft(CABG) or Aortic/Mitral valve replacement (VR) surgery.

NCT ID: NCT03195595 Recruiting - Clinical trials for Mitral Valve Disease

Minimal Invasive Mitral Valve Replacement Versus Conventional Median Sternotomy Approach

Start date: April 1, 2020
Phase:
Study type: Observational

This is retrospective study that will be done in Cardiothoracic surgery department in Assuit university hospitals for one year duration aiming to compare minimal invasive technique to conventional median sternotomy for mitral valve surgery regarding early postoperative outcomes and pain