Mitochondrial Diseases Clinical Trial
Official title:
Can Red Light Lift Droopy Eyelids? An Open-label Proof-of-concept Study
This study tests a new treatment to help with droopy eyelids (ptosis) and eye movement problems (squint) in children and young people with genetically confirmed mitochondrial conditions - using red-light. We use a torch to shine a red light through the closed eyelid for 3 minutes a day. The study will run for 18 months. We believe that this treatment could help strengthen the muscle in the eyelid to make it easier to open the eyes, and could also help some children with squint.
| Status | Recruiting |
| Enrollment | 10 |
| Est. completion date | November 30, 2025 |
| Est. primary completion date | November 30, 2025 |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | 3 Years to 18 Years |
| Eligibility | Inclusion: Age 3 to less than 18 years Genetically confirmed diagnosis of primary mitochondrial disease (known pathogenic mutation(s) in mitochondrial or nuclear DNA known to cause primary mitochondrial disease) Ptosis Exclusion: Genetic diagnosis not consistent with primary mitochondrial disease. No genetic diagnosis Unable to cooperate with light treatment or ophthalmological assessments. |
| Country | Name | City | State |
|---|---|---|---|
| United Kingdom | Moorfields Eye Hospital NHS Foundation Trust | London |
| Lead Sponsor | Collaborator |
|---|---|
| University College, London | Moorfields Eye Hospital NHS Foundation Trust |
United Kingdom,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Palpebral fissure width | 3 months from baseline |
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