Missed Abortion Clinical Trial
Official title:
The Role of Uterine Artery Doppler Parameters in the Management of Retained Products of Conception.
During the recent decades the need for surgical evacuation of the uterus in early
miscarriages and incomplete miscarriages has been questioned.
It has been shown that an observational approach can be, in many cases, as good as an
invasive one without increasing the incidence of uterine infections.
it has been shown that misoprostol - prostaglandin E1 given for missed abortions is
successful in emptying the uterus in 85% of cases without any need for surgical
intervention. and during recent years many women prefer this approach than the surgical one
.
Many have tried using sonographic signs such as endometrial thickness, the presence of a
gestational sac, and color doppler to differ between blood clots and a gestational residua
in uterus, and to decide according to these signs wether there is a need for surgical
evacuation or an expectant management could be used. but none of these methods have been
proven to be completely efficient as predictors.
In this study the investigators will examine whether the doppler indices in the uterine
arteries can help to predict which gestational residua needs surgical evacuation of the
uterus and which could be managed expectantly.
The study hypothesis is that the resistance in uterine artery doppler will be lower in cases
with intrauterine residua as opposed to high resistance in cases without residua.
Status | Recruiting |
Enrollment | 200 |
Est. completion date | January 2015 |
Est. primary completion date | January 2015 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 20 Years to 45 Years |
Eligibility |
Inclusion Criteria:1. women with missed abortion (embryo karger than 5 mm with no heart
beat) or anembryonic pregnancy (empty gestational sac larger than 20 mm) 2. incomplete
abortion 3. missed abortion with CRL (crown ump length) no larger than 8 weeks of
pregnancy 4. women who got a clear explanation about all treatment options and they chose
misoprostol as a treatment 5. women who read and signed an informed consent form Exclusion Criteria: 1. known allergy to prostaglandins or NSAIDS 2. heavy vaginal bleeding and hemodynamic instability 3. multifetal gestation 4. women with a clotting problems or treated with anticoagulant medications 5. fever above 37.5 c 6. anemia with hemoglobin < 9/5 gr% 7. missed abortion with CRL larger than 8 weeks of pregnancy 8. diseases that can be aggravated by prostaglandins : severe asthma, uncontrolled blood pressure, glaucoma, sickle cell anemia, mitral stenosis |
Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
Israel | Carmel Medical Center | Haifa |
Lead Sponsor | Collaborator |
---|---|
Carmel Medical Center |
Israel,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | uterine artery doppler parameters | comparison between uterine artery doppler parameters after complete abortion with misoprostol to doppler parameters in incomplete abortion with the need of surgical uterine evacuation. and in result to try and find a doppler value that could be used to predict the success of observational management in incomplete abortions or abortions with misoprostol. | 1 year | No |
Secondary | success rate of treatment of misoprostol in missed and incomplete abortions | 1 year | No |
Status | Clinical Trial | Phase | |
---|---|---|---|
Not yet recruiting |
NCT01639976 -
Doppler Flow Measurements in Patients With Misoprostol Treatment for Arrested Pregnancy
|
N/A | |
Recruiting |
NCT03628625 -
Letrozole Pretreatment With Misoprostol fInduction of Abortion In First-Trimester Missed Miscarriage
|
Phase 2 | |
Completed |
NCT03584698 -
Evening Primrose Oil to Misoprostol During Induction of Second-trimester Missed Miscarriage
|
Phase 4 | |
Active, not recruiting |
NCT05516810 -
The Accuracy of Ultrasound Diagnosis of Hydatidiform Moles
|
||
Not yet recruiting |
NCT04590482 -
Letrozole Pretreatment With Misoprostol Induction of Abortion in First Trimester Missed Abortion
|
Phase 4 | |
Recruiting |
NCT05342467 -
Gemeprost Versus Dinoprostone in First Trimester Miscarriages
|
Phase 2 | |
Recruiting |
NCT03698734 -
Evening Primrose Oil Efficacy in Second Trimester Abortion
|
Phase 3 | |
Terminated |
NCT01615224 -
Repeated Doses of Misoprostol for Medical Treatment of Missed Miscarriage
|
Phase 2/Phase 3 | |
Completed |
NCT05216952 -
Ulipristal Acetate for Use in Early Pregnancy Loss
|
Phase 2 | |
Recruiting |
NCT03081104 -
Operative Hysteroscopy and Ultrasound Guided Vacuum Aspiration Versus Blind Vacuum Aspiration for the Treatment of Missed Abortion
|
N/A | |
Completed |
NCT00892229 -
Buccal Versus Vaginal Misoprostol in Surgical Termination of the First Trimester Missed Abortion in Erbil
|
Phase 2 | |
Active, not recruiting |
NCT04981457 -
Comparative Study Between Combined Vaginal Misoprostol
|
Phase 1 | |
Not yet recruiting |
NCT06469203 -
Oxytocin Effectiveness in First Trimester Dilatation and Curettage - a Double Blind Placebo Controlled Randomized Trial
|
N/A | |
Recruiting |
NCT02573051 -
Termination Of Anembryonic Pregnancy
|
Phase 2 | |
Not yet recruiting |
NCT04217265 -
Letrozole Pretreatment With Misoprostol Versus Misoprostol Alone in Missed Abortion
|
Phase 4 | |
Not yet recruiting |
NCT04215835 -
Letrozole Pretreatment With Misoprostol Induction of Abortion In First-Trimester Missed Miscarriage
|
Phase 4 | |
Recruiting |
NCT04705324 -
Dilation and Curettage Versus Operative Hysteroscopy for Missed Abortion
|
N/A | |
Completed |
NCT02686840 -
Sublingual Versus Vaginal Misoprostol In Medical Treatment of First Trimestric Missed Miscarriage
|
Phase 3 | |
Terminated |
NCT02342002 -
Mifepristone and Misoprostol Versus Misoprostol Alone for Missed Abortion: A Randomized-controlled Trial
|
Phase 4 | |
Active, not recruiting |
NCT04593108 -
Misoprostol With or Without Letrozole in Treatment of Missed Miscarriage
|