Treatment of Misophonia: Comparison of Exposure and Sound Therapy

Misophonia Clinical Trial

Official title:

Treatment of Misophonia: Comparison of Exposure and Sound Therapy

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05993286
• Other study ID #: 16969557
• Status: Completed
• Phase: N/A
• Start date: March 1, 2019
• Est. completion date: April 1, 2021

Study information

• Verified date: August 2023
• Source: Hacettepe University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The goal of this clinical trial is to compare the effects of possible treatments in misophonics. The main question it aims to answer is:

• Is exposure more effective on misophonic symptoms than sound therapy? Participants are randomly assinged to three groups of treatment;

1. Psychoeducation

2. Psychoeducation + Exposure

3. Psychoeducation + Sound Therapy

Recruitment information / eligibility

• Status: Completed
• Enrollment: 76
• Est. completion date: April 1, 2021
• Est. primary completion date: April 1, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• People have Misophonia

Exclusion Criteria:

• Current psychosis

• Mental retardation or dementia

• those who had previously received exposure or sound therapy for misophonia symptoms.

Related Conditions & MeSH terms

• Misophonia

Intervention

Behavioral:
• Exposure Therapy
At Week 0, the homework was to expose oneself to these sounds for 20 minutes a day, three days a week for three weeks. At the Week 3 interview, the frequency and severity of the homework were adjusted based on the degree of improvement in the symptoms and the person's adherence to the instructions.

Other:
• Sound Therapy
Participants were asked to listen to specifically modulated music for twenty minutes a day, three days a week, for the first three weeks. At the Week 3 assessment, if the patient reported no or little benefit in their misophonia symptoms, the instruction was modified (intensified) to listening to the same music for forty minutes a day, three days a week.
• Psychoeducation
A psychoeducation session, prepared by the research team was delivered by the investigator to each patient at the study intake.

Locations

Country	Name	City	State
Turkey	Hacettepe University Department of Psychiatry	Ankara

Sponsors (1)

Lead Sponsor	Collaborator
Hacettepe University

Country where clinical trial is conducted

Turkey, 

References & Publications (3)

Jager IJ, Vulink NCC, Bergfeld IO, van Loon AJJM, Denys DAJP. Cognitive behavioral therapy for misophonia: A randomized clinical trial. Depress Anxiety. 2020 Dec 18;38(7):708-18. doi: 10.1002/da.23127. Online ahead of print. — View Citation

Kilic C, Oz G, Avanoglu KB, Aksoy S. The prevalence and characteristics of misophonia in Ankara, Turkey: population-based study. BJPsych Open. 2021 Aug 6;7(5):e144. doi: 10.1192/bjo.2021.978. — View Citation

Swedo SE, Baguley DM, Denys D, Dixon LJ, Erfanian M, Fioretti A, Jastreboff PJ, Kumar S, Rosenthal MZ, Rouw R, Schiller D, Simner J, Storch EA, Taylor S, Werff KRV, Altimus CM, Raver SM. Consensus Definition of Misophonia: A Delphi Study. Front Neurosci. 2022 Mar 17;16:841816. doi: 10.3389/fnins.2022.841816. eCollection 2022. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	The mean change in Misophonia Total Score (MTS)	The difference between MTS Week 0 and MTS Week 6 was calculated, divided by MTS Week 0, and multiplied by 100, to elicit the percent change in MTS between Week 0 and Week 6.	Week 0 and Week 6
Primary	The "improvement"	It was rated by the investigator (KBA) based on her clinical judgement (0=some worsening, 1=no improvement, 2=some improvement, 3=moderate improvement, 4=much improvement). If there was a moderate to much improvement at any point, the case was rated as "improved"; and "not improved" if the score was little worsening, no improvement, or some improvement.	Week 3 and Week 6