Miscarriage Clinical Trial
Official title:
Letrozole Pretreatment With Misoprostol for Induction of Abortion In First-Trimester Missed Miscarriage: A Randomized Controlled Trial
This study compares the success rate of letrozole and misoprostol versus misoprostol alone for medical termination of first trimester pregnancy.
According to the American college of obstetricians and gynecologists (2005), medical abortion
is an acceptable alternative for surgical procedures in pregnant women with gestational age
of less than 49 days based on the last menstrual period
Oral or vaginal misoprostol causes complete abortion in almost 85% of cases within seven days
before the 12th week
letrozole administration with misoprostol raises the rate of complete abortion
Hypothesis:
In women with missed miscarriage in the first trimester undergoing induction of abortion
pre-treatment with letrozole before misoprostol may lead to abortion rate similar to
misoprostol alone.
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