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BRAINI-2 Elderly Mild TBI European Study — BRAINI2ELDER  

Mild Traumatic Brain Injury Clinical Trial

Official title:
Blood Biomarkers to Improve Management of Mild Traumatic BRAIN Injury in the Elderly

Clinical Trial Summary

Mild traumatic brain injury (mTBI) is one of the most frequent emergencies in the elderly population. Despite most mTBI are managed with cranial computed tomography (CT), only 10% of CTs show lesions, determining CT overuse. The use of serum glial fibrillary acidic protein (GFAP) and Ubiquitin C-terminal Hydrolase-L1 (UCH-L1) have shown potential for ruling out the need for cranial CT. However evidence on biomarker use in mild TBI were not based on studies that included aged participants and patients with comorbidities for which biomarker levels could vary. This is why there is a need for a prospective study that assesses the predictive performance of these two biomarkers in the elderly population, both in elderly patients suffering mild TBI and in a reference population, including patients and participants with and without comorbidities.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05425251
Study type Observational
Source Hospital Universitario 12 de Octubre
Contact Alfonso Lagares Gómez-Abascal, MD, PhD
Phone +34917792839
Email alfonso.lagares@salud.madrid.org
Status Recruiting
Phase
Start date March 1, 2022
Completion date June 30, 2024
View Details
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