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Clinical Trial Summary

This study aims to assess the effect and safety of erenumab compared to placebo for the treatment of acute posttraumatic headache (PTH) in military service members and civilians with mild traumatic brain injury (mTBI).


Clinical Trial Description

Headache is recognized as one of the most common and disabling symptoms following head trauma. This study is designed to assess a calcitonin gene-related peptide (cGRP) monoclonal antibody (erenumab) for the preventive treatment of PTH based on the rationale that headache posttrauma is similar to migraine and is mediated by the activation of the trigeminal vascular system and subsequent release of cGRP. This study is a randomized, double-blind, placebo-controlled study to assess the safety, tolerability, and efficacy of erenumab 140 mg for the treatment of PTH in military service members and civilians with mTBI at military treatment facilities across the United States. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05049057
Study type Interventional
Source Henry M. Jackson Foundation for the Advancement of Military Medicine
Contact Amy Guthrie, RN
Phone 202-924-2729
Email amy.guthrie.ctr@usuhs.edu
Status Recruiting
Phase Phase 2
Start date July 19, 2022
Completion date May 19, 2027

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