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Mild Depression clinical trials

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NCT ID: NCT05594667 Withdrawn - Depression Clinical Trials

Effect of SSRIs on Response to Psilocybin Therapy

Start date: January 1, 2023
Phase: Phase 2
Study type: Interventional

This study is an open-label, single-arm, within-subjects design in individuals with mild-moderate Major Depressive Disorder (MDD). All participants will receive a single dose of 25mg of psilocybin in a therapeutic setting. In order to investigate the effects of length of time on SSRI therapy, 30 participants with varying lengths of time on SSRI therapy will be enrolled, stratified into four groups: - Group 1: ≤ 1 year - Group 2: 1 to ≤ 5 years - Group 3: 5 to ≤ 10 years - Group 4: > 10 years