Behavioral Interventions to Prevent or Delay Dementia

Mild Cognitive Impairment Clinical Trial

Official title: Comparative Effectiveness of Behavioral Interventions to Prevent or Delay Dementia (CEBIPODD)

Status Completed

Clinical Trial Summary

This study will compare the effectiveness of different combinations of 5 types of behavioral interventions across patient-centered outcomes. It will also evaluate which outcomes (e.g. quality of life, cognition, function, mood) matter most to people at risk for dementia and their care partners. The results of this study have the potential to direct patients, families, and health care providers as to which combinations of behavioral interventions provide the greatest potential impact on which dementia prevention outcomes. Greater use of behavioral strategies that are targeted to the outcomes of most important to the patient will likely improve patient compliance and treatment adherence. This, in turn, can lessen the need for medication, health care, and long term care utilization.

Clinical Trial Description

Traditional randomized controlled trials (RCTs) can be thought of as 'additive' trials where randomization leads to the addition of treatments beyond placebo. Participants are confronted with the probability of receiving placebo (no treatment). This leads many potential participants to not consent or to withdraw if they believe they are receiving no treatment. In contrast, the proposed trial will be 'subtractive'. This innovative approach to randomization will involve suppression of just 1 of the 5 treatment components. Thus, all participants will receive at least 80% of the menu of interventions offered in this trial. ;

Related Conditions & MeSH terms

• Alzheimer Disease
• Amnestic Disorder
• Cognition Disorders
• Cognitive Dysfunction
• Dementia
• Dementia and Amnestic Conditions
• Disease
• Impaired Cognition
• Memory Disorders
• Memory Impairment
• Mild Cognitive Disorder
• Mild Cognitive Impairment
• Mild Dementia
• Poor Short-term Memory

• NCT number: NCT02265757
• Study type: Interventional
• Source: Mayo Clinic
• Status: Completed
• Phase: N/A
• Start date: June 2014
• Completion date: March 31, 2018