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Mild Cognitive Impairment clinical trials

View clinical trials related to Mild Cognitive Impairment.

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NCT ID: NCT06278818 Recruiting - Clinical trials for Mild Cognitive Impairment

Effects of Telerehabilitation on Brain Network Connectivity

Start date: December 7, 2023
Phase: N/A
Study type: Interventional

The current project aims at assessing the impact of various cognitive telerehabilitation approaches on patients with Mild Cognitive Impairment (MCI) associated with neurodegenerative diseases, namely Alzheimer's disease (AD) and Parkinson's disease (PD). The study focuses on non-pharmacological interventions to maintain patients' residual functionality, limit disease progression, and improve quality of life for both patients and their caregivers. This longitudinal and multicenter study applies innovative cognitive telerehabilitation (TR) methods and evaluates their impact on functional parameters obtained with high-density electroencephalogram (HD-EEG) and resting-state functional magnetic resonance imaging (rsFMRI). The goal is to identify neurophysiological correlates of the effects of three different cognitive TR in individuals with MCI due to neurodegenerative conditions. The study aims to: - Identify correlations between improvement in cognitive performance and functional brain data. - Use acquired knowledge to develop neurologically guided TR approaches for broader use. The research will include patients diagnosed with MCI associated with neurodegenerative diseases. Primary outcome measures include changes in resting-state brain connectivity assessed through HD-EEG and rsFMRI. Secondary outcomes involve the assessment of changes in neuropsychological measures, caregiver burden, immediately after rehabilitation and after longitudinal follow-up. The study is designed to last 30 months, with follow-up assessments at three time points. The primary outcomes will be evaluated using rsFMRI and HD-EEG instrumental acquisitions, the secondary outcomes will be evaluated using clinical assessments and neuropsychological tests.

NCT ID: NCT06264557 Recruiting - Clinical trials for Mild Cognitive Impairment

Cognitive Therapy Software for Improving Cognitive Function for Patients With Mild Cognitive Impairment

SB-DEX
Start date: January 17, 2024
Phase: N/A
Study type: Interventional

Cognitive therapy software for improving cognitive function for patients with mild cognitive impairment

NCT ID: NCT06254040 Recruiting - Clinical trials for Mild Cognitive Impairment

Effect of Consuming a Mixture of Extracts and DHA on the Mild Cognitive Impairment

Start date: July 1, 2022
Phase: N/A
Study type: Interventional

The objective of this trial is to evaluate the effect of the consumption of a mixture of extracts and DHA on the mild cognitive impairment.

NCT ID: NCT06252844 Recruiting - Clinical trials for Mild Cognitive Impairment

The Impact of 6-months of Resistance Training on Brain and Muscle Health in Older Adults With MCI

Start date: February 15, 2024
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to learn about the effect of long resistance training intervention on brain and muscle health in older adults with mild cognitive impairment (MCI). The main question it aims to answer is whether progressive resistance training can prevent/delay neurodegenerative/pro-inflammatory processes that are detrimental to cognition, mobility, vitality, and mental health of older adults with MCI. Participants will undergo 6 months of supervise resistance training. Subjects in the intervention group will undergo sessions of structural and functional magnetic resonance imaging, proton magnetic resonance spectroscopy at baseline and end of intervention. Blood analyses and functional and cognitive tests will be performed at baseline after 3 months from the start of intervention and at the end of the intervention. Observations obtained from the intervention group will compare to data collected from age-matched active control group who will undergo flexibility training of lower limb muscles.

NCT ID: NCT06245707 Recruiting - Clinical trials for Mild Cognitive Impairment

the Effects of Different Treatment Schemes on Cognitive Function of Patients With Idiopathic Membranous Nephropathy

Start date: October 1, 2023
Phase: N/A
Study type: Interventional

This study intends to apply prospective, open, single-center, randomized controlled study to evaluate the cognitive status of patients with Idiopathic membranous nephropathy and the influence of different treatment schemes on the cognitive status of patients with Idiopathic membranous nephropathy, and explore the possible pathophysiological mechanism by using brain magnetic resonance imaging technology.

NCT ID: NCT06236646 Recruiting - Clinical trials for Mild Cognitive Impairment

Effects of Thai Dance With Twenty-five Squares in Elderly With Mild Cognitive Impairment

Start date: January 3, 2024
Phase: N/A
Study type: Interventional

The objective of this study was to determine the effects of Thai dance with twenty-five squares on cerebrovascular and cognitive function in elderly with mild cognitive impairment

NCT ID: NCT06227364 Recruiting - Dementia Clinical Trials

Prediction, Prevention, Predisposition: Applications in Neurology and Endocrinology

PRECUBE2022
Start date: March 8, 2023
Phase:
Study type: Observational

This project aims to introduce solutions for strengthening the management capabilities of two types of patients, in terms of care and prevention. Specifically, it is aimed at neurological patients with mild or minor neurocognitive decline (Mild Cognitive Impairment, MCI) and endocrinological patients diagnosed with obesity. The study want to enhance the predictive capacity of the care process management system through an Artificial Intelligence (AI) system. All patients diagnosed with MCI and obesity who, within 30 months, will be referred to the Neurology and Endocrinology clinics of the IRCCS Centro Neurolesi Bonino-Pulejo in Messina will be evaluated. Study design Patients will not be subjected to any procedure that goes beyond normal clinical practice; the clinical and neuropsychological variables that will be collected for the study are those that are commonly collected in normal clinical practice. All patients diagnosed with MCI and obesity who, within 30 months, will be referred to the Neurology and Endocrinology clinics of the IRCCS Centro Neurolesi Bonino-Pulejo in Messina will be evaluated. All patients will undergo clinical, neuropsychological and psychological evaluation at the beginning (baseline T0), at the end (T1) and after ... months from the end of treatment (follow up T2).

NCT ID: NCT06221202 Recruiting - Alzheimer Disease Clinical Trials

Stories in the Moment: Dance Program for People Living With Dementia

Start date: February 10, 2023
Phase: N/A
Study type: Interventional

This study is designed to evaluate the impact on the quality of life and wellbeing of a person-centered online dance program on people living with dementia or MCI and care partners. The duration of the study will be 1 year. Each participant in the study will be followed for approximately 4 months. The study includes joining a weekly 1-hour dance program online on Zoom for 12 weeks. Prior and after the dance program, participants will meet with the research coordinator to answer some questionnaires about wellbeing and reflections on their experience in the program. After the completion of the dance program, participants will be invited to join a focus group to reflect of the impact of the program with fellow participants. The study will enroll up to 72 participants. This includes 36 dyads of persons living with dementia or MCI and their care partners. The study will enroll community-dwelling people living with a diagnosis of mild cognitive impairment or mild to moderate-stage dementia and care partners living in the United States.

NCT ID: NCT06201533 Recruiting - Clinical trials for Mild Cognitive Impairment

Low-intensity Physical-cognitive Exercise and Cognitive Function

Start date: April 7, 2024
Phase: N/A
Study type: Interventional

This study aims to examine the effects of low-intensity, combined physical-cognitive exercise on cognitive function of older people with mild cognitive impairment (MCI) and identify the mechanisms by which this exercise protocol exerts cognitive function. Older adults with MCI will be recruited to either an exercise or a control group. Low-intensity, combined physical-cognitive exercise will be prescribed to the exercise group 3 times per week for 3 months while the control group will maintain their routine lifestyle. It is hypothesized that at the end of the trial, participants in the exercise group will demonstrate significant improvement in cognitive performance and circulating biomarkers compared to baseline and the control group.

NCT ID: NCT06198530 Recruiting - Clinical trials for Mild Cognitive Impairment

Nurse-led Clinics Training Program on Mild Cognitive Impairment Patients

Start date: January 15, 2024
Phase: N/A
Study type: Interventional

This trail is the first study to test the efficacy of nurse-led clinics cognitive training on mild cognitive impairment (MCI) patients using a single-blind, randomized controlled trial design. The investigators hypothesize that nurse-led clinics cognitive training can (a)decelerate or ameliorate cognitive decline, (b)ameliorate anxiety and depressive symptoms, (c)increase the quality of life for both patients and family members, (d)improve the ability of daily life, (e)reduce the incidence of agitation.