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Effect of Levcromakalim in Individuals With Migraine Pretreated With Erenumab — COLLIDE  

Migraine Without Aura Clinical Trial

Official title:
Effect of Levcromakalim in Individuals With Migraine Pretreated With Erenumab: A Randomized Double-Blind Placebo-Controlled Two-Way Crossover Trial

Clinical Trial Summary

An outstanding scientific question, that merits further investigation, is whether dilation of intracranial arteries is implicated in the pathogenesis of cephalic pain in migraine. Here, we hypothesize that experimentally-induced dilation of intracranial arteries using intravenous infusion of levcromakalim (a potent vasodilator) induces cephalic pain with migraine-like features in people with migraine, who prior to the infusion are administered erenumab (anti-calcitonin gene-related peptide (CGRP) receptor monoclonal antibody).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05889442
Study type Interventional
Source Danish Headache Center
Contact
Status Completed
Phase N/A
Start date March 9, 2023
Completion date June 12, 2023
View Details
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