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Migraine Without Aura clinical trials

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NCT ID: NCT06244823 Recruiting - Migraine Disorders Clinical Trials

The FreMRI Study: Advanced MRI on Migraine Patients Treated With Fremanezumab

FreMRI
Start date: March 1, 2023
Phase: Phase 4
Study type: Interventional

The goal of this open-label, single-blind, controlled-trial is to evaluate brain changes evaluated with diffusion Magnetic Resonance Imaging (MRI) and functional MRI in patients with high-frequency episodic migraine and chronic migraine that will be treated with Fremanezumab, 12 weeks after the treatment onset, compared with the baseline. Type of study: Phase IV clinical trial Participant population: high-frequency episodic migraine and chronic migraine. Participants will be treated with Fremanezumab.

NCT ID: NCT06051604 Recruiting - Migraine Clinical Trials

Mi-Helper Transnasal Cooling for Acute Treatment of Migraine

Start date: November 15, 2023
Phase: N/A
Study type: Interventional

This is a prospective, double-blind, sham-controlled, randomized two-part clinical trial with an adaptive design. This study aims to assess the efficacy, safety, tolerability, and the optimal dose of the Mi-Helper transnasal cooling device for acute treatment of migraine in an at home setting. This study will be conducted in two parts. The first part of this study aims to determine the most effective dose of Mi-Helper and the second part aims to evaluate the efficacy, safety, and tolerability of the most effective dose of the Mi-Helper device for the acute treatment of episodic migraine in adults. Adults aged 18 years to 65 years old with a diagnosis of episodic migraine (with or without aura) for at least one year (self-reported) will be recruited for this study.

NCT ID: NCT06023953 Completed - Clinical trials for Migraine Without Aura

Migraine With and Without Aura Response to Remote Electrical Neuromodulation (REN) Treatment

Start date: July 1, 2023
Phase:
Study type: Observational

This is a Post-marketing study investigating the safety and efficacy of the acute treatment of migraine with a Remote Electrical Neuromodulation (REN) device (Nerivio) in migraine patients with and without aura, as well as characterizing demographic and attack characteristic differences between migraine patients with and without aura. Safety will be assessed by the number and type of device-related adverse events. Efficacy will be evaluated as a change in headache pain severity from baseline to 2 hours post-treatment. Disease characteristics will look into demographic and attack differences between patients with and without aura.

NCT ID: NCT05903040 Recruiting - Migraine Clinical Trials

Ditan Acute tReatments: Effectiveness and Tolerability (DART)

DART
Start date: June 15, 2023
Phase:
Study type: Observational

The purpose of this prospective and multicentric study is to evaluate the effectiveness and tolerability of lasmiditan as acute migraine treatment in a cohort of episodic or chronic migraine patients.

NCT ID: NCT05903027 Recruiting - Migraine Clinical Trials

Gepant treAtments: EffectIveNess and tolERability (GAINER)

GAINER
Start date: June 15, 2023
Phase:
Study type: Observational

The purpose of this prospective and multicentric study is to evaluate the effectiveness and tolerability of rimegepant as acute migraine treatment in a cohort of episodic or chronic migraine patients.

NCT ID: NCT05889624 Recruiting - Migraine Clinical Trials

Responding With Evidence and Access for Childhood Headaches

Start date: August 22, 2023
Phase: N/A
Study type: Interventional

This comparative effectiveness study will clarify current first-line preventive treatment approaches for use by neurologists, psychologists, and primary care providers in the context of real world care, and will demonstrate the feasibility of Cognitive Behavioral Therapy (CBT) via telehealth for youth with migraine. The focus is on applying evidence-based care and enhancing access to it. CBT via telehealth while taking a clinically-prescribed, pill-based prevention therapy (amitriptyline) will be compared to CBT via telehealth alone.

NCT ID: NCT05889455 Completed - Clinical trials for Migraine Without Aura

Effect of Sildenafil in Individuals With Migraine Pretreated With Erenumab

COMPETE
Start date: April 20, 2023
Phase: N/A
Study type: Interventional

An outstanding scientific question, that merits further investigation, is whether dilation of intracranial arteries is implicated in the pathogenesis of cephalic pain in migraine. Here, we hypothesize that experimentally-induced dilation of intracranial arteries using intake of sildenafil (a potent vasodilator) can induce cephalic pain with migraine-like features in people with migraine, who prior to the infusion are administered erenumab (anti-calcitonin gene-related peptide (CGRP) receptor monoclonal antibody.

NCT ID: NCT05889442 Completed - Clinical trials for Migraine Without Aura

Effect of Levcromakalim in Individuals With Migraine Pretreated With Erenumab

COLLIDE
Start date: March 9, 2023
Phase: N/A
Study type: Interventional

An outstanding scientific question, that merits further investigation, is whether dilation of intracranial arteries is implicated in the pathogenesis of cephalic pain in migraine. Here, we hypothesize that experimentally-induced dilation of intracranial arteries using intravenous infusion of levcromakalim (a potent vasodilator) induces cephalic pain with migraine-like features in people with migraine, who prior to the infusion are administered erenumab (anti-calcitonin gene-related peptide (CGRP) receptor monoclonal antibody).

NCT ID: NCT05750446 Not yet recruiting - Clinical trials for Migraine Without Aura

Effect of Riocigaut on Migraine Attack Induction and Cerebral Vasodilation in Migraine Patients.

Start date: April 1, 2023
Phase: N/A
Study type: Interventional

This double-blind, randomized, placebo-controlled cross-over clinical trial aims to investigate the effects of riocigaut on migraine inducing properties and cerebral arteries in patients with migraine.

NCT ID: NCT05679908 Completed - Chronic Migraine Clinical Trials

A Study to Evaluate the Efficacy and Safety of TNX-1900 in Patients With Chronic Migraine

PREVENTION
Start date: December 6, 2022
Phase: Phase 2
Study type: Interventional

This is a phase 2, double-blind, randomized, multicenter, placebo-controlled, three arm parallel study to evaluate the efficacy and safety of two different dosages (30 IU daily and 60 IU daily) of TNX-1900 in patients with chronic migraine.