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Evaluation of the Efficacy of Almotriptan and Ubrogepant for the Acute Treatment of Migraine — ATOM  

Migraine Without Aura Clinical Trial

Official title:
A Randomized, Parallel-Group, Single-Attack, Open-Label Study to Evaluate the Efficacy of Almotriptan and Ubrogepant for the Acute Treatment of Migraine (ATOM).

Clinical Trial Summary

In a real-world population of adults with migraine, the investigators would like to investigate whether 12.5 mg almotriptan is non-inferior to 50 mg ubrogepant in terms of pain freedom at 2 hours after drug intake.

Clinical Trial Description

The study is a randomized, open-label, parallel-group, single-attack study with 12.5 mg almotriptan and 50 mg ubrogepant. 645 patients with migraine with or without aura according to the third edition of the International Classification of Headache Disorders (ICHD-3) will be included. Each subject will randomly be allocated to one treatment, and given 42 days to treat a single qualifying migraine attack of moderate to severe intensity. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05214001
Study type Interventional
Source Danish Headache Center
Contact Messoud Ashina, Prof.
Phone 004538633385
Email messoud.ashina@regionh.dk
Status Recruiting
Phase Phase 4
Start date June 30, 2022
Completion date December 2025
View Details
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