Migraine Without Aura Clinical Trial
Official title:
Investigation of PACAP38 Induced Headache, Migraine and Flushing in Patients With Migraine
The aim is to investigate the incidence of headache, migraine attacks and flushing after pituitary adenylate cyclase-activating peptide-38 (PACAP38) with and without treatment with sumatriptan in patients with migraine
Pituitary adenylate cyclase-activating peptide-38 (PACAP38) plays a role in migraine
pathophysiology. Infusions of PACAP38 can trigger migraine-like attacks in some migraine
patients and will induce flushing in all patients. We are investigating whether treatment
with sumatriptan has an effect on the PACAP38-induced flushing and on whether headache and
migraine is induced.
The purpose of this study is to investigate PACAP38-induced headache and migraine in patients
with migraine who have been treated with either sumatriptan or placebo using
purpose-developed standardized interview. The study will be conducted with a double-blind,
placebo-controlled crossover study design.
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