Migraine Without Aura Clinical Trial
Official title:
Amylin and CGRP Migraine Provocation in Migraine Without Aura Patients
Amylin and calcitonin gene related peptide (CGRP) are related to the same peptide family. Both share 16 out of 37 amino acids and can activate each others receptor. CGRP is implicated in migraine pathophysiology but the role of Amylin and its receptor in migraine is not fully clarified.
Amylin is a peptide hormone that binds to a G-protein coupled receptor (GPCR). amylin was
originally found in the pancreas (Beta Cell of Islets of Langerhans) but also shown to be
present in the trigeminal ganglion, hind horn ganglia and perivascular nerve fibers.
Amylin has many similarities with CGRP. Amylin and CGRP share 16 out 37 amino acids. Both
peptides can activate the amylin 1 subtype (AMY1)receptor with high affinity and reported to
have more similar physiological and pharmacological effects.
In addition, both peptides increase the intracellular concentration of cyclic AMP (cAMP)
which has a central role in migraine pathophysiology.
The aim of the study is pin point the role of amylin and amylin receptor compare to CGRP in
migraine pathophysiology.
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