Migraine Without Aura Clinical Trial
Official title:
PACAP Induced Migraine Attacks in Patients With High and Low Genetic Load
The investigators hypothesized that migraine without patients with many genetic loci associated with migraine (high genetic load) would be more sensitive and get provoked more migraine attacks by PACAP compared to patients with few genetic loci associated with migraine (low genetic load).
Migraine is a very prevalent neurological disorder with a strong genetic factor. The common
forms of migraine have a multifactorial and polygenic pattern of inheritance and genetics
research is crucial for a deeper understanding of migraine mechanisms. Recently, 12 genetic
loci have been identified to be associated with migraine with (MA) and without aura (MA) in
four large genome-wide association studies (GWAS). The functional consequences of this
genetic variant in humans are yet unknown.
PACAP is a neuropeptide which plays a crucial role in the pathophysiology of migraine and is
present in migraine relevant structures. PACAP can induce migraine attacks in MO patients
via an adenosine monophosphate (cAMP) dependent pathway. Also, a recent study has showed
that intracellular accumulation of cAMP is crucial for the induction of migraine attacks.
The phenotype of the migraine inducing effects of PACAP might therefore be linked to some of
the 12 genetic susceptibility loci that have been identified.
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Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor)
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