Migraine Without Aura Clinical Trial
Official title:
The Effect of PACAP38 and VIP on Migraine Patients Assessed by a 3-Tesla MR Scanner
The purpose of this study is to examine and compare the effect of pituitary adenylate
cyclase-activating polypeptide-38 (PACAP38) and vasoactive intestinal polypeptide (VIP) on
intracranial arteries and neuronal activity in patients with migraine without aura using a
high resolution magnetic resonance imaging (MRI), including MR angiography (MRA) and
functional MRI (fMRI).
MRA will be used to detect changes in intracranial artery circumferences before and after
PACAP38 and VIP.
fMRI will be used oo detect changes in blood-oxygenation-level-dependent-signal
(BOLD-signal).
PACAP38 but not VIP induces migraine like attacks in migraine patients. The migraine
specific drug sumatriptan will be given to relieve pain and the effect will also be
registered using MRA and fMRI.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
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