Migraine Disorders Clinical Trial
Official title:
Resting-state Functional Connectivity Changes During Migraine Treatment: a Structural and Functional MRI Follow-up Study
The purpose of this study is to determine whether reduced frequency of migraine attacks are associated with signal alternation and connectivity of cerebral cortex.
Patients with migraine show reduced cortical thickness in regions subserving pain processing,
and it is related to increasing headache frequency. In the past, only one study has shown a
reversibility consequence of chronic nociceptive transmission, which normalizes when the pain
is adequately treated. However, little is known whether these changes predispose to migraine
or represent the effect of repeated migraine attacks. Our region of interest is reduced
frequency of migraine attacks are associated with reversibility of signal alternation and
functional connectivity of cerebral cortex.
In 30 migraineurs with 8-14days with headache per months who already performed brain magnetic
resonance imaging will be recruited. Treatment medications such as frovatriptan and
topiramate will be used for 6 months. After 6 months, follow-up brain magnetic resonance
imaging will be performed.
The primary outcome is the longitudinal changes in functional connectivity in
pain-processing/modulating brain regions. The secondary outcome is following: 1)longitudinal
changes in structural and morphological alterations in brain regions of pain processing;
2)structural, morphological, and functional correlates of treatment response; 3)changes in
monthly migraine days, migraine frequecies, headache days, and headache frequencies after
treatment; 4)responses to acute migraine treatment.
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