Clinical Trials Logo

Clinical Trial Summary

Intestinal floras and their metabolites are involved in progressing metabolic and cardiovascular diseases. However, currently, articles related to the relationship between intestinal floras and atherosclerosis mainly focus on coronary atherosclerotic disease (CAD) population, or atherosclerosis model animals such as ApoE-/-, LDLR-/- high-fat diet mice, and there are few studies on Chronic limb-threatening ischemia (CLTI). CLTI and CAD have a similar pathological basis of atherosclerosis. It is unclear whether intestinal flora plays an essential role in the occurrence and development of CLTI. This project aims to explore the relation between microorganisms, metabolites, and CLTI.


Clinical Trial Description

This project aims to study the intestinal flora and its metabolites in patients with CLTI, explore whether CLTI patients and CAD patients have their own characteristic flora, analyze the microorganisms and metabolites markers of poor prognosis in patients with CLTI, and screen out the key differential bacteria and metabolites that inhibit the progress of CLTI, in order to provide new insights and research basis for the treatment of CLTI. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06220994
Study type Observational [Patient Registry]
Source Beijing Tsinghua Chang Gung Hospital
Contact
Status Enrolling by invitation
Phase
Start date November 15, 2021
Completion date May 15, 2025

See also
  Status Clinical Trial Phase
Recruiting NCT05288790 - Microbiome Metabolites and Alcohol in HIV to Reduce CVD RCT Phase 2
Recruiting NCT05963659 - Nitrate Modulates Cognitive Impairment Via Oral Microbiota. N/A
Completed NCT04130321 - Demonstration of the Prebiotic-like Effects of Camu-camu Consumption Against Obesity-related Disorders in Humans N/A
Recruiting NCT05929976 - InterNatIonal CHildhood Leukemia Microbiome/MEtabolome Cohort
Withdrawn NCT04230746 - Effect of Antibiotics on Urinary Microbiome Early Phase 1
Active, not recruiting NCT06289283 - Microbiota in Urine and Urothelium Can be a Factor for Induction of Urinary Bladder Cancer. The Study Will Examine Urine and Bladder Cancer Tissues From Male Patients and Urine of Controls Using Whole Genomic Sequencing Techniques and 16S rRNA. The Aim is to Elucidate Role of Microbiota in Bladder
Recruiting NCT05714566 - Research on Gut Microbiome and Metabolomics Alterations in C.Difficile Infected IBD Patients
Enrolling by invitation NCT06225336 - Subcutaneous Implant Combination Product (AUR-201) in Patients With Unilateral Microtia (Australia) Phase 1
Recruiting NCT05068362 - Auricular Reconstruction in Microtia by Medpor Implant Following Tissue Expansion N/A
Completed NCT02224677 - Craniofacial Microsomia: Longitudinal Outcomes in Children Pre-Kindergarten (CLOCK)
Not yet recruiting NCT05615116 - Clinical Study on the Distribution of Digestive Tract Microbiota Before and After Ileocecal Resection in Crohn's Disease
Completed NCT00958802 - Tissue Engineering Microtia Auricular Reconstruction: in Vitro and in Vivo Studies Phase 0
Recruiting NCT06087874 - Preventive Effect of Perinatal Oral Probiotic Supplementation (POPS) on Neonatal Jaundice Phase 2
Suspended NCT03624608 - Evaluation of the Auryzon Devices in the Optimization of Ear and Nose Reconstruction Procedures N/A
Not yet recruiting NCT06394687 - The Digestion of Protein Powders in Healthy Participants Using SIMBA and LIMBA Capsule N/A
Completed NCT05417360 - Akkermansia and Weight Maintenance N/A
Recruiting NCT02518035 - Silicone Gel to Improve Scar in Microtia Patients Phase 4
Recruiting NCT06078566 - Long-Term Follow-Up Study of Unilateral Microtia Patients Implanted With AUR-201 Phase 1/Phase 2
Recruiting NCT06072040 - Subcutaneous Implant Combination Product (AUR-201) in Patients With Unilateral Microtia Phase 1/Phase 2
Not yet recruiting NCT03729427 - Rib Microtia and the Erector Spinae Plane (ESP) Block N/A