Microtia Clinical Trial
Official title:
The Gut Microbiome and Metabolomics Among Chronic Lower Extremities Threatening Ischemia Patients in China - a Prospective Observational Study
Intestinal floras and their metabolites are involved in progressing metabolic and cardiovascular diseases. However, currently, articles related to the relationship between intestinal floras and atherosclerosis mainly focus on coronary atherosclerotic disease (CAD) population, or atherosclerosis model animals such as ApoE-/-, LDLR-/- high-fat diet mice, and there are few studies on Chronic limb-threatening ischemia (CLTI). CLTI and CAD have a similar pathological basis of atherosclerosis. It is unclear whether intestinal flora plays an essential role in the occurrence and development of CLTI. This project aims to explore the relation between microorganisms, metabolites, and CLTI.
This project aims to study the intestinal flora and its metabolites in patients with CLTI, explore whether CLTI patients and CAD patients have their own characteristic flora, analyze the microorganisms and metabolites markers of poor prognosis in patients with CLTI, and screen out the key differential bacteria and metabolites that inhibit the progress of CLTI, in order to provide new insights and research basis for the treatment of CLTI. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05288790 -
Microbiome Metabolites and Alcohol in HIV to Reduce CVD RCT
|
Phase 2 | |
Recruiting |
NCT05963659 -
Nitrate Modulates Cognitive Impairment Via Oral Microbiota.
|
N/A | |
Completed |
NCT04130321 -
Demonstration of the Prebiotic-like Effects of Camu-camu Consumption Against Obesity-related Disorders in Humans
|
N/A | |
Recruiting |
NCT05929976 -
InterNatIonal CHildhood Leukemia Microbiome/MEtabolome Cohort
|
||
Withdrawn |
NCT04230746 -
Effect of Antibiotics on Urinary Microbiome
|
Early Phase 1 | |
Active, not recruiting |
NCT06289283 -
Microbiota in Urine and Urothelium Can be a Factor for Induction of Urinary Bladder Cancer. The Study Will Examine Urine and Bladder Cancer Tissues From Male Patients and Urine of Controls Using Whole Genomic Sequencing Techniques and 16S rRNA. The Aim is to Elucidate Role of Microbiota in Bladder
|
||
Recruiting |
NCT05714566 -
Research on Gut Microbiome and Metabolomics Alterations in C.Difficile Infected IBD Patients
|
||
Enrolling by invitation |
NCT06225336 -
Subcutaneous Implant Combination Product (AUR-201) in Patients With Unilateral Microtia (Australia)
|
Phase 1 | |
Recruiting |
NCT05068362 -
Auricular Reconstruction in Microtia by Medpor Implant Following Tissue Expansion
|
N/A | |
Completed |
NCT02224677 -
Craniofacial Microsomia: Longitudinal Outcomes in Children Pre-Kindergarten (CLOCK)
|
||
Not yet recruiting |
NCT05615116 -
Clinical Study on the Distribution of Digestive Tract Microbiota Before and After Ileocecal Resection in Crohn's Disease
|
||
Completed |
NCT00958802 -
Tissue Engineering Microtia Auricular Reconstruction: in Vitro and in Vivo Studies
|
Phase 0 | |
Recruiting |
NCT06087874 -
Preventive Effect of Perinatal Oral Probiotic Supplementation (POPS) on Neonatal Jaundice
|
Phase 2 | |
Suspended |
NCT03624608 -
Evaluation of the Auryzon Devices in the Optimization of Ear and Nose Reconstruction Procedures
|
N/A | |
Not yet recruiting |
NCT06394687 -
The Digestion of Protein Powders in Healthy Participants Using SIMBA and LIMBA Capsule
|
N/A | |
Completed |
NCT05417360 -
Akkermansia and Weight Maintenance
|
N/A | |
Recruiting |
NCT02518035 -
Silicone Gel to Improve Scar in Microtia Patients
|
Phase 4 | |
Recruiting |
NCT06078566 -
Long-Term Follow-Up Study of Unilateral Microtia Patients Implanted With AUR-201
|
Phase 1/Phase 2 | |
Recruiting |
NCT06072040 -
Subcutaneous Implant Combination Product (AUR-201) in Patients With Unilateral Microtia
|
Phase 1/Phase 2 | |
Not yet recruiting |
NCT03729427 -
Rib Microtia and the Erector Spinae Plane (ESP) Block
|
N/A |