Effect of Anesthetics on Microcirculation in Patients Undergoing Off-pump Coronary Artery Bypass Surgery

Microcirculation Clinical Trial

Official title:

Effect of Anesthetics on Microcirculation in Patients Undergoing Off-pump Coronary Artery Bypass Surgery

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03209193
• Other study ID #: OPCAB_SEVO vs DES
• Status: Completed
• Phase: Phase 4
• Start date: July 4, 2017
• Est. completion date: November 7, 2019

Study information

• Verified date: March 2020
• Source: Seoul National University Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Volatile anesthetics, such as sevoflurane and desflurane, are commonly used in patients undergoing cardiac surgeries including off-pump coronary artery bypass. However, the effect of volatile anesthetics on microcirculation in patients undergoing off-pump coronary artery bypass has not been well conducted.

Description:

This is a prospective randomized clinical trial investigating the effect of sevoflurane vs. desflurane on tissue microcirculation in patients undergoing off-pump coronary artery bypass surgery. Eligible patients are going to be randomized to receive sevoflurane or desflurane, as a maintenance anesthetic, during the surgery. Tissue oxygen saturation and microcirculatory changes, such as an occlusion and recovery slope, during vascular occlusion test will be recorded during the surgery. The primary end point of the study is the difference in tissue oxygen saturation between the groups.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 72
• Est. completion date: November 7, 2019
• Est. primary completion date: November 7, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 20 Years to 90 Years

Eligibility

Inclusion Criteria:

• scheduled for off-pump coronary artery bypass surgery

Exclusion Criteria:

• any deformity or vascular abnormalities on upper arms

• cannot receive sevoflurane or desflurane for any reason (muscular diseases, etc)

• uncontrolled diabetes

• peripheral vascular disease

• severe renal dysfunction (end-stage renal disease)

• refuse to enroll

• pregnant

Related Conditions & MeSH terms

• Anesthetic Complication Spinal
• Microcirculation

Intervention

Drug:
• Sevoflurane
Sevoflurane use as main anesthetic drug during the surgery
• Desflurane
Desflurane use as main anesthetic drug during the surgery

Locations

Country	Name	City	State
Korea, Republic of	Seoul National University Hospital	Seoul

Sponsors (1)

Lead Sponsor	Collaborator
Seoul National University Hospital

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Tissue oxygen saturation measured at thenar eminence by Hutchinson(R) tissue oximeter during off-pump coronary artery bypass surgery	Tissue oxygen saturation measured at thenar eminence by tissue oximeter during surgery in patients receiving sevoflurane or desflurane	Before induction of anesthesia to the end of the surgery, an average 8 hours