Microcirculation Clinical Trial
Official title:
Effect of Dexmedetomidine on Microcirculation in Patients Undergoing Extracorporeal Shock Wave Lithotripsy
Dexmedetomidine administration for minor procedure, such as extracorporeal shock wave
lithotripsy, provides good quality of sedation and analgesia. Dexmedetomidine is a highly
selective α2-adrenergic receptor agonist which causes sedative effects and reduces opioid
requirements in the perioperative period. Extracorporeal shock wave lithotripsy may cause
pain and result in tachycardia and vasoconstriction-related hypertension. Surgical or
procedural stress may induce inflammation and it may cause further microthrombosis. Both
vasoconstriction and microthrombosis will alter the microcirculatory status. Dysfunction of
microcirculation may impair tissue perfusion and result in organ dysfunction.
Dexmedetomidine may induce vasodilation by slow intravenous infusion for sedation.
Dexmedetomidine may also reduce inflammation. After reviewing the literature, the
investigators found that the effect of dexmedetomidine on microcirculation was not well
investigated. By application of the non-invasive technique of sidestream dark field imaging,
the investigators can investigate the vessel density, percentage of perfused vessels, and
microvascular flow index on sublingual vessels.
The goal of this study is to identify the effect of dexmedetomidine on sublingual
microcirculation in patient undergoing extracorporeal shock wave lithotripsy.
n/a
Endpoint Classification: Pharmacodynamics Study, Intervention Model: Single Group Assignment, Masking: Open Label
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Not yet recruiting |
NCT04982016 -
Effects of Fluid Therapy on Microcirculatory Reactivity
|
N/A | |
| Recruiting |
NCT01204554 -
Microcirculation in Perforator Flaps. Enhancing Tissue Survival
|
Phase 0 | |
| Completed |
NCT00810927 -
Role of Nitrogen Oxide (NO) in the Control of Choroidal Blood Flow During a Decrease in Ocular Perfusion Pressure
|
Phase 2 | |
| Completed |
NCT04773899 -
COVID-19 Associated Endothelial Dysfunction Study
|
N/A | |
| Completed |
NCT01024543 -
Role of Angiotensin II in Insulin-induced Microvascular Activity
|
N/A | |
| Recruiting |
NCT05681052 -
Mottling Score and Central Venous Oxygen Saturation in Septic Shock Patients
|
||
| Recruiting |
NCT05606536 -
The Impact of Intra-operative Fluid Infusion Rate on Microcirculation
|
N/A | |
| Completed |
NCT02466594 -
Impact of Active Thermoregulation on the Microcirculation of Free Flaps
|
N/A | |
| Completed |
NCT04500197 -
A Study of MIcrocirculatory Perfusion Alterations in Severe Burn Injury
|
||
| Completed |
NCT04550026 -
Cardiovascular Effects of Heated Tobacco Products (HTP)
|
N/A | |
| Recruiting |
NCT04294316 -
Enhanced-contrast Brain Ultrasound in Cardiorespiratory Arrest
|
N/A | |
| Completed |
NCT03357523 -
Evaluation of Peripheral Microcirculation Hemodynamics Following Various Changes Based on Noninvasive Thermography
|
N/A | |
| Terminated |
NCT04962048 -
The Influence of Pulse-synchronized Negative Pressure on the Dermal Microcirculation
|
N/A | |
| Completed |
NCT02511899 -
Investigation of the Influence of Careless™, a Mangifera Indica Fruit Powder, on Microcirculation and Endothelial Function
|
N/A | |
| Completed |
NCT02688946 -
Imaging Microcirculation and Gross Hemodynamics in Elective Colorectal Surgery
|
N/A | |
| Completed |
NCT02549378 -
Study of the Impact of Changes in Carbonemia on Microcirculation in Patients Achieving a Test Hypercapnia
|
N/A | |
| Completed |
NCT00335010 -
Intravenous NTG to Preserve Gastric Microcirculation During Gastric Tube Reconstruction
|
N/A | |
| Active, not recruiting |
NCT04169204 -
Very Old Intensive Care Patients - Perfusion
|
||
| Recruiting |
NCT04290767 -
Brain Ultrasound With Contrast Microbubbles Injection in Shock Status
|
N/A | |
| Completed |
NCT03089814 -
Changes in Tissue Microcirculation During Ischemic Conditioning: Pilot Study
|
N/A |