Summary of Infants Weighing 500 Grams or Less

Status Completed

Clinical Trial Summary

This is a retrospective single-center cohort study. The comparison in short- and long-term outcomes will be made between those with and without primary microcephaly in infants weighing ≤ 500 g.

Clinical Trial Description

This is a retrospective single-center cohort study. The study setting is a level IV neonatal intensive care unit (NICU) at Nagano Children's Hospital in Nagano, Japan. We will retrospectively collect the data of those who were admitted to Nagano Children's Hospital NICU between January 1, 2015, and December 31, 2019. Eligible infants will be identified using our neonatal database and clinical records. The extracted data includes maternal background information and clinical course, infant's status at birth, the clinical course in NICU, and the follow-up data at 6 and 18 months of corrected age. Among the eligible infants, those with a z score of birth head circumference < -2 will be classified into the Microcephaly group and others into the Control group. The z score is calculated using the Japanese growth standard. ;

Study Design

Related Conditions & MeSH terms

Birth Weight
Infant, Extremely Low Birth Weight
Microcephaly

Clinical Trial Details

NCT number	NCT05322980
Study type	Observational
Source	Nagano Children's Hospital
Contact
Status	Completed
Phase
Start date	April 5, 2022
Completion date	December 31, 2022

View Details

See also
Status	Clinical Trial	Phase
Active, not recruiting	`NCT03548779` - North Carolina Genomic Evaluation by Next-generation Exome Sequencing, 2	N/A
Completed	`NCT02510170` - Fetal and Maternal Head Circumference During Pregnancy in Israeli Population	N/A
Completed	`NCT01565005` - Microcephaly Genetic Deficiency in Neural Progenitors	N/A
Terminated	`NCT03922594` - Surveillance of Zika-related Microcephaly in Sub-Saharan Africa and Asia
Completed	`NCT02943304` - Neurodevelopment Outcome of Newborns Exposed to Zika Virus (ZIKV) in Utero
Recruiting	`NCT06019182` - MEHMO Natural History and Biomarkers
Completed	`NCT03330600` - Efficacy of Aquatic Physiotherapy in Children With Microcephaly by Zika Virus Congenital Syndrome	N/A
Recruiting	`NCT03255369` - Vertical Exposure to Zika Virus and Its Consequences for Child Neurodevelopment (ZIKVIRUSIFF)
Recruiting	`NCT03325946` - The FBRI VTC Neuromotor Research Clinic
Completed	`NCT02741882` - Zika and Microcephaly: Case-control Study	N/A
Recruiting	`NCT05518188` - Melpida: Recombinant Adeno-associated Virus (Serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt)	Phase 1/Phase 2
Recruiting	`NCT03651687` - Guangzhou Surveillance and Clinical Study in Microcephaly (GSCSM)
Completed	`NCT00001639` - Evaluation of Patients With Unresolved Chromosome Abnormalities	N/A
Withdrawn	`NCT01151462` - Postnatal HCMV Infection in Very Preterm Infants. Implications, Morbidity, Growth and Neurodevelopmental Outcomes.
Completed	`NCT04816175` - Intensive Therapy for Children With Microcephaly, Hyperkinetic Movements, or Global Developmental Delay	N/A