Microbiota Clinical Trial
— FiberPlayOfficial title:
Effects of Soluble Dietary Fiber on Sport Efficiency and Fatigue Delay in Top Basketball Players
Verified date | February 2023 |
Source | University of Zagreb |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Athlete nutrition is becoming an increasingly important factor on the path to achieving top results. Nutrients such as soluble fiber can alter the intestinal microbiota, resulting in metabolites with a positive effect on metabolism. Thus, the fibers become available, an additional source of energy to the host, have an anti-stress effect and delay the feeling of fatigue. The primary goal of the study is to determine the impact of soluble dietary fiber on increasing athletic efficiency, the secondary goal is to determine the impact of fiber on delaying fatigue. Subjects will be randomly divided into experimental and control group. The sample of variables will consist of genome microbiota genome sequencing data, measures to assess morphological characteristics, lower extremity explosive strength tests, and cardiovascular endurance. The statistical package SPSS will be used for data processing. The expected scientific contribution of this research is to expand the scientific knowledge about the importance of dietary fiber in the diet of athletes with the aim of improving sports performance.
Status | Completed |
Enrollment | 20 |
Est. completion date | December 20, 2021 |
Est. primary completion date | October 31, 2021 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 18 Years to 22 Years |
Eligibility | Inclusion Criteria: - Professional basketball players from the same team participating in the same monitored training process Exclusion Criteria: - Diabetes or other chronic disease, taking sports performance enhancing drugs, taking antibiotics 3 months prior or during the course of the study |
Country | Name | City | State |
---|---|---|---|
Croatia | Faculty of Food Technology and Biotechnology | Zagreb |
Lead Sponsor | Collaborator |
---|---|
University of Zagreb | Croatian Science Foundation |
Croatia,
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* Note: There are 11 references in all — Click here to view all references
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Rapid microbiota change | The impact of fiber supplementation on gut microbiome shall assessed through monitoring of relative taxonomic abundance of bacteria that compose gut microbiota. DNA shall be extracted from collected faecal samples, stored at -80°C. DNA extraction shall be performed using the QIAamp® PowerFecal® DNA Kit. DNA concentration shall be quantified using Promega Quantus Flourometer before being sent to amplicon sequencing of variable regions 3 and 4 of the 16S rRNA gene with the primer set 341F (5'-CCTAYGGGRBGCASCAG -3') 806R (5'- GGACTACNNGGGTATCTAAT -3'). Obtained sequenceing raw data (reads) shall be analyzed using 'Quantitative Insights Into Microbial Ecology 2' (QIIME2) software in order to evaluate microbial composition of each sample. The comparison on intial sample (before intervention) and sample 1 (after 2 weeks) of supplementation shall provide a baseline insight into eventual rapid microbiota change as a response to supplementation/placebo. | 2 weeks | |
Primary | Altered microbiota composition | Prolonged supplementation after initial 2 weeks will support the established altered gut microbiota in participants receiving fiber supplement. The impact of fiber supplementation on gut microbiome shall assessed through monitoring of relative taxonomic abundance of bacteria that compose gut microbiota. Gut microbiota DNA shall be extracted from collected faecal samples, stored at -80°C. DNA shall be processed in the same manner as previously described (Outcome 1). Obtained sequenceing raw data (reads) shall be analyzed using 'Quantitative Insights Into Microbial Ecology 2' (QIIME2) software in order to evaluate microbial composition of each sample. The comparison on intial sample (before intervention) and sample 2 (after 4 weeks) of supplementation shall provide an insight into eventual microbiota change as a response to prolonged supplementation/placebo. | 4 weeks | |
Primary | Effect on the perception of fatigue | The major question is whether the moderately increasing fiber intake in athletes has the potential to support the intestinal microbiota and conversely positively impact training-induced perception of fatigue. In order to understand the impact of fiber consumption on the perception of fatigue, after each training session or match, the participants shall be asked to record and send a rating of perceived exertion through a mobile messaging application. The Borg's CR10 RPE scale shall be used for this purpose. This scale has a range from 0 to 10 (RPE - Rating of Perceived Exertion). The RPE scale is a tool used to monitor the perceptual response to training, as a method of determining physical exertion during exercise. The original RPE scale, developed more than 40 years ago, was primarily used to monitor aerobic load, but it still remains widely used in athlete tracking. | 4 weeks | |
Secondary | Long-term microbiota impact | After total of 8 weeks fiber supplementation, one additional microbiota composition measurement (16S rRNA sequencing of donated fecal samples after 8 weeks of trial) will be taken after additional 4 weeks with no supplementation (intervention), in order to determine if the initial microbiota change caused by fiber supplementation can persist without additional fiber supplementation and to assess the potential for a long-term induced microbiota change. The comparison on intial sample (before intervention), sample 1 (after 2 weeks) of supplementation and sample 2 (after 4 weeks) with sample 3 (after 8 weeks) shall provide a baseline insight into microbiota change as a response to supplementation/placebo. DNA extraction and data processing shall be the same as in previous outcomes. | 8 weeks |
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