Effects of Intravenous (IV) Omadacycline on Gut Microbiome

Status Recruiting

Clinical Trial Summary

Given the clinical need to improve upon current antibiotic regimens for the treatment of C. difficile infection with a particular focus on the impact of therapies on gut microbiome, this study proposes to characterize the impact of Intravenous (IV) omadacycline on gut microbiome of healthy volunteers.

Clinical Trial Description

The plan to enroll eight healthy volunteers between the ages of 18 and 40 years and without history of cardiovascular, gastrointestinal, hepatic, or renal disease to receive 5 days of intravenous omadacycline followed by 5 days of oral omadacycline. Stool and saliva samples will be collected at pre-specified times and analyzed to characterize the impact of IV omadacycline on gut microbiome. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05515562
Study type	Interventional
Source	Wake Forest University Health Sciences
Contact	Yolanda Belin
Phone	336-716-3720
Email	ybelin@wakehealth.edu
Status	Recruiting
Phase	Phase 4
Start date	March 20, 2023
Completion date	October 2024

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