Urine Omics Predicting IO Therapy Responses in mUC Patients

Status Recruiting

Clinical Trial Summary

The study aims to identify urinary metabolite and protein markers that can predict anti-tumor efficacy and adverse events in subjects receiving IO-based therapies for metastatic urothelial carcinoma.

Clinical Trial Description

This is a multi-center single-arm translational study where patients with mUC who are about to receive pre-determined IO-based anti-tumor therapy will be invited to participate the study. After signing the approved informed consent, eligible and consenting subjects will donate their fresh urine samples for subsequent untargeted metabolomics and proteomics study via GS-MS/MS and/or LC-MS/MS to identify potential metabolite and protein markers that are able to predict efficacy and side effects of IO-based therapies. All subjects in the first-line, maintenance after 1st line, second-line, or subsequent lines of IO-based therapy will be invited and recruited, but those who have received any IO-based therapy before the study can NOT be recruited. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04641936
Study type	Observational
Source	National Taiwan University Hospital
Contact	Yeong Shiau Pu, MD PhD
Phone	886-2-23123456
Email	pu5249@ntuh.gov.tw
Status	Recruiting
Phase
Start date	December 17, 2020
Completion date	October 31, 2027

View Details

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