| Eligibility |
Inclusion Criteria:
1. Be willing and able to provide written informed consent/assent for the trial, and be
willing and able to follow trial procedures.
2. Be 18 years-old on day of signing informed consent.
3. Have an histologically-confirmed diagnosis of UC of the bladder or the urothelium,
originating from either the bladder or the urinary tract (including upper tract), with
predominant (>50%) UC component if other divergent histologies (e.g. squamous cell
carcinoma, adenocarcinoma, small cell carcinoma) are found.
4. Have a life expectancy of at least 12 weeks.
5. Have experienced failure of 1 or 2 platinum-based conventional chemotherapy regimens
for metastatic disease (2nd-to-3rd line only); a relapse should be occurred within 6
months from the last cycle of chemotherapy.
6. Have measurable disease based on RECIST 1.1.
7. Be willing to provide tissue from a newly obtained core or excisional biopsy of a
tumor lesion. Newly-obtained is defined as a specimen obtained up to 6 weeks (42 days)
prior to initiation of treatment on Day 1. Subjects for whom newly-obtained samples
cannot be provided (e.g. inaccessible or subject safety concern) may provide an
archived specimen.
8. Have a performance status of 0 or 1 on the Eastern Cooperative Oncology Group (ECOG)
Performance Scale.
9. Demonstrate adequate organ function.
10. (Female subject of childbearing potential) Have a negative urine or serum pregnancy
within 72 hours prior to receiving the first dose of study medication. If the urine
test is positive or cannot be confirmed as negative, a serum pregnancy test will be
required.
11. (Female subjects of childbearing potential ) Be willing to use an adequate method of
contraception for the course of the study through 120 days after the last dose of
study medication.
12. (Male subjects of childbearing potential) Agree to use an adequate method of
contraception, starting from the first dose of study therapy through 120 days after
the last dose of study therapy.
Exclusion Criteria:
1. Is currently participating and receiving study therapy or has participated in a study
of an investigational agent and received study therapy or used an investigational
device within 4 weeks of the first dose of treatment.
2. Has a diagnosis of immunodeficiency or is receiving systemic steroid therapy or any
other form of immunosuppressive therapy within 7 days prior to the first dose of trial
treatment
3. Has a known history of active Bacillus Tuberculosis
4. Had prior administration of taxane-based chemotherapy
5. Is taking regular oral steroids, above the allowed limit of 10mg/day
methylprednisolone or analogues, for any reason. Patients must not have had steroids
for 28 days prior to study entry
6. Has had a prior anti-cancer monoclonal antibody (mAb) within 4 weeks prior to study
Day 1 or who has not recovered (i.e., Grade =1 or at baseline) from adverse events due
to agents administered more than 4 weeks earlier
7. Has had prior chemotherapy, targeted small molecule therapy, or radiation therapy
within 2 weeks prior to study Day 1 or who has not recovered (i.e., = Grade 1 or at
baseline) from adverse events due to a previously administered agent
- Note: Subjects with Grade =2 neuropathy are an exception to this criterion and
may qualify for the study
- Note: If subject received major surgery, they must have recovered adequately from
the toxicity and/or complications from the intervention prior to starting therapy
8. Has a known additional malignancy that is progressing or requires active treatment.
Exceptions include basal cell carcinoma of the skin or squamous cell carcinoma of the
skin that has undergone potentially curative therapy or in situ cervical cancer
9. Has known active central nervous system (CNS) metastases and/or carcinomatous
meningitis. Subjects with previously treated brain metastases may participate provided
they are stable (without evidence of progression by imaging for at least four weeks
prior to the first dose of trial treatment and any neurologic symptoms have returned
to baseline), have no evidence of new or enlarging brain metastases, and are not using
steroids for at least 7 days prior to trial treatment. This exception does not include
carcinomatous meningitis which is excluded regardless of clinical stability
10. Has active autoimmune disease that has required systemic treatment in the past 2 years
(i.e. with use of disease modifying agents, corticosteroids or immunosuppressive
drugs). Replacement therapy (eg., thyroxine, insulin, or physiologic corticosteroid
replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a
form of systemic treatment
11. Has a history of (non-infectious) pneumonitis that required steroids or current
pneumonitis.
12. Has an active infection requiring systemic therapy.
13. Has a history or current evidence of any condition, therapy, or laboratory abnormality
that might confound the results of the trial, interfere with the subject's
participation for the full duration of the trial, or is not in the best interest of
the subject to participate, in the opinion of the treating investigator
14. Has known psychiatric or substance abuse disorders that would interfere with
cooperation with the requirements of the trial
15. Is pregnant or breastfeeding, or expecting to conceive or father children within the
projected duration of the study, starting with the screening visit through 120 days
after the last dose of trial treatment.
16. Has received prior therapy with an anti-PD-1, anti-PD-L1, or anti-PD-L2 agent
17. Has a known history of Human Immunodeficiency Virus (HIV) (HIV 1/2 antibodies)
18. Has known active Hepatitis B or Hepatitis C
19. Has received a live vaccine within 30 days of planned start of study therapy
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