| Eligibility |
Inclusion Criteria:
Participants are eligible to be included in the study only if all of the following criteria
apply:
1. Relapsed / Recurrent histologically confirmed B3-Thymoma or TC patients not amenable
to curative-intent radical surgery and/or radiotherapy, regardless of PD-L1
expression.
2. Patients progress after at least one previous line of platinum-based chemotherapy for
advanced disease:
a. Patients treated with neo-adjuvant or adjuvant platinum-based chemotherapy combined
with radical surgery or as part of radical chemo-radiotherapy are eligible if
chemotherapy was completed within 6 months before enrollment.
3. Negative result for Myasthenia Gravis (MG) by acetylcholine receptor antibodies test.
Note: Acetylcholine receptor antibodies test should be performed within 6 months prior
to screening visit.
4. Male/female who are at least 18 years of age on the day of signing informed consent.
5. ECOG performance status 0-1
6. Life expectancy = 3 months
7. Radiological progression documented per RECIST 1.1 during or after completion of
previous line therapy, per investigator's criteria.
8. Presence of measurable disease according to RECIST criteria. Lesions situated in a
previously irradiated area are considered measurable if progression has been
demonstrated in such lesions.
a. Disease status must be documented by full chest and upper abdomen (including
adrenal glands) CT and/or MRI within 28 days prior study enrollment. If clinically
indicated, brain imaging must be performed;
9. Provides historical (obtained archived FFPE) or fresh tumor biopsy specimen for
biomarker studies, if feasible. Archival tumor tissue sample or newly obtained core or
excisional biopsy of a tumor lesion not previously irradiated is acceptable.
Formalin-fixed, paraffin embedded (FFPE) tissue blocks are preferred to slides. Newly
obtained biopsies are preferred to archival tissue. Note: If submitting unstained cut
slides, newly cut slides should be submitted to the testing laboratory within 14 days
from the date slides are cut.
10. A female participant is eligible to participate if she is not pregnant, not
breastfeeding, and at least one of the following conditions applies:
1. Not a woman of childbearing potential (WOCBP) OR
2. A WOCBP who agrees to follow the contraceptive guidance during the treatment
period and for at least 6 months after the last dose of study treatment.
11. Has adequate bone marrow and organ function. Specimens must be collected within 10
days prior to the start of study treatment.
12. Written informed consent prior to beginning specific protocol procedures.
Exclusion Criteria:
Participants are excluded from the study if any of the following criteria apply:
1. Has received prior therapy with an anti-PD-1, anti-PD-L1, or anti PD L2 agent or with
an agent directed to another stimulatory or co-inhibitory T-cell receptor (e.g.,
CTLA-4, OX 40, CD137).
2. Has received prior therapy with sunitinib.
3. Any evidence of active central nervous system (CNS) metastases and/or carcinomatous
meningitis. Patients with previously treated brain metastases may participate provided
they are clinically stable (i.e. without evidence of progression by imaging for at
least four weeks prior to enrollment and any neurologic symptoms have returned to
baseline), and have not received steroids (for a total equivalent dose of more than 10
mg of prednisone per day) for at least 7 days prior to enrollment.
4. Uncontrolled blood pressure (Systolic BP>140 mmHg or diastolic BP >90 mmHg) in spite
of an optimized regimen of antihypertensive medication.
5. Significant cardiovascular impairment: history of congestive heart failure greater
than New York Heart Association (NYHA) Class II, unstable angina, myocardial
infarction or stroke within 6 months of the first dose of study drug, or cardiac
arrhythmia requiring medical treatment at Screening.
6. Intratumor cavitation, direct invasion of main mediastinal blood vessels by the tumor
or exist previous bleeding.
7. Subjects having > 1+ proteinuria on urine dipstick testing unless a 24-hour urine
collection for quantitative assessment indicates that the urine protein is <1 g/24
hours.
8. Has received prior investigational agents within 4 weeks prior to allocation.
9. Participants must have recovered from all AEs due to previous therapies to = Grade 1
or baseline. Participants with = Grade 2 neuropathy may be eligible.
10. If participant received major surgery, they must have recovered adequately from the
toxicity and/or complications from the intervention prior to starting study treatment.
If surgery is needed during treatment, lenvatinib will be withheld for at least 1 week
prior to elective surgery and until at least 2 weeks following major surgery and
adequate wound healing. The safety of resumption of lenvatinib after resolution of
wound healing has not been established.
11. Fraction ejection < 50%.
12. Known history or current evidence of active Hepatitis B (e.g., HBsAg reactive) or C
(e.g., HCV RNA [qualitative] is detected) or Human Immunodeficiency Virus (HIV)
(HIV-1/2 antibodies).
13. If CT has to be used, known contra-indications for CT with IV contrast.
14. Chronic use of immunosuppressive agents and/or systemic corticosteroids or any use in
the last 15 days prior to enrolment:
a. Daily prednisone at doses up to 10 mg or equivalent doses of any other
corticosteroid is allowed for example as replacement therapy.
15. History of interstitial lung disease (ILD) OR pneumonitis (other than COPD
exacerbation) that has required oral or IV steroids.
16. Active autoimmune disease that has required systemic treatment in the past 2 years
(i.e. with use of disease modifying agents, corticosteroids or immunosuppressive
drugs). Replacement therapy (i.e., thyroxine, insulin, or physiologic corticosteroid
replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a
form of systemic treatment and is allowed.
17. Has received a live vaccine within 30 days prior to the first dose of study drug.
Examples of live vaccines include, but are not limited to, the following: measles,
mumps, rubella, varicella/zoster (chicken pox), yellow fever, rabies, Bacillus
Calmette-Guérin (BCG), and typhoid vaccine. Seasonal influenza vaccines for injection
are generally killed virus vaccines and are allowed; however, intranasal influenza
vaccines (e.g., FluMist®) are live attenuated vaccines and are not allowed.
18. Autoimmune disorders requiring immunosuppressive or dedicated treatment.
19. History of any other hematologic or primary solid tumor malignancy, unless in
remission for at least 5 years and without specific treatment (as example, not allowed
hormonal therapy to replace for breast cancer or hormonal therapy substitution in
prostate cancer). pT1-2 prostatic cancer Gleason score < 6, superficial bladder
cancer, non-melanomatous skin cancer or carcinoma in situ of the cervix are allowed.
20. Previous allogenic tissue/solid organ transplantation
21. Active infection requiring systemic therapy
22. A WOCBP who has a positive urine pregnancy test within 72 hours prior to allocation
(see Appendix 3). If the urine test is positive or cannot be confirmed as negative, a
serum pregnancy test will be required.
Note: in the event that 72 hours have elapsed between the screening pregnancy test and
the first dose of study treatment, another pregnancy test (urine or serum) must be
performed and must be negative in order for subject to start receiving study
medication.
23. Has received prior radiotherapy within 2 weeks of start of study treatment.
24. Has severe hypersensitivity (= Grade 3) to pembrolizumab and/or any of its excipients;
known sensitivity or intolerance to lenvatinib and/or any of its excipients; severe
hypersensitivity to monoclonal antibody-containing regimen.
25. Has a history or current evidence of any condition, therapy, or laboratory abnormality
that might confound the results of the study, interfere with the subject's
participation for the full duration of the study, or is not in the best interest of
the subject to participate, in the opinion of the treating investigator.
26. Has known psychiatric or substance abuse disorders that would interfere with
cooperation with the requirements of the trial.
27. Has an intestinal disease not allowing swallowing pills.
28. Is pregnant or breastfeeding or expecting to conceive or father children within the
projected duration of the study, starting with the screening visit through the 6
months after the last dose of trial treatment.
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