| Eligibility |
Inclusion Criteria:
- 18 years or older
- Signed written informed consent
- Diagnosis of RCC with clear-cell or predominant clear-cell histology (= 50% other
histologic features)
- Subjects with recurrent or refractory, metastatic disease (N1 or M1) fulfilling any of
the following combinations of pathologic staging based on American Joint Committee on
Cancer (AJCC) TNM staging version 2010 and Fuhrman nuclear grading
- pT3, G any, N1; or, pT4, G any, N1; or, pT any, G any, N1 or M1)
- Subjects have already undergone all standard of care surgery appropriate for stage of
disease.
- Eastern Cooperative Oncology Group (ECOG) Performance Status =2.
- Serum albumin =3.0 gm/dL.
- Adequate organ function including:
1. Marrow: Hemoglobin =10.0 gm/dL, absolute granulocyte count (AGC) =1,000/mm3,
platelets =75,000/mm3, absolute lymphocyte count =475/mm3.
2. Hepatic: Serum total bilirubin =2.5 x upper limit of normal (ULN), ALT (SGPT) and
AST (SGOT) =2.5 x ULN.
3. Renal: Serum creatinine (sCr) = 2.0 x upper limit of normal.
- Patients must have the ability to understand the study, its risks, side effects,
potential benefits and be able to give written informed consent to participate.
Patients may not be consented by a durable power of attorney (DPA).
- Male and female subjects of child producing potential must agree to use contraception
or avoidance of pregnancy measures while enrolled on study and receiving the
experimental drug, and for one month after the last immunization.
- Patients who have received previous systemic therapies including TKI inhibitors are
eligible.
Exclusion Criteria:
- Age <18-years-old.
- Active CNS metastases or carcinomatous meningitis. Patients with CNS lesions that have
been treated and who have no evidence of progression in the brain on CT/MRI for =1
month are eligible.
- Pregnant or nursing women due to the unknown effects of immunization on the developing
fetus or newborn infant.
- Other malignancy within five years, except that the following may be eligible:
- patients curatively treated for localized squamous or basal cell carcinoma of the skin
or for carcinoma in situ of the uterine cervix (CIN) or breast,
- Patients with a history of malignant tumor who have been disease free for at least
five years and are not currently being treated.
- History of an allogeneic solid organ transplant or bone marrow transplant, or current
active immunosuppressive therapy such as cyclosporine, tacrolimus, etc.
- Subjects taking systemic (parentally or orally) corticosteroid therapy for any reason,
including replacement therapy for hypoadrenalism, are not eligible. Topical steroids
are acceptable as are intranasal steroids.
- Active infection or antibiotics within 48 hours prior to study enrollment, including
unexplained fever (temp > 38.1°C), if deemed clinically significant by the treating
physician.
- Evidence of active autoimmune disease (e.g., systemic lupus erythematosis, rheumatoid
arthritis, with the exception of vitiligo. Patients with a remote history of asthma or
mild asthma are eligible.
- Other serious medical conditions that may be expected to limit life expectancy to less
than 1 year (e.g., liver cirrhosis).
- Any condition, psychiatric or otherwise, that would preclude informed consent,
consistent follow-up or compliance with any aspect of the study (e.g., untreated
schizophrenia or other significant cognitive impairment, etc).
- Patients having previously undergone splenectomy.
- Patients with known hepatitis or unstable liver disease, and/or positive serologies
for Hepatitis B or C and HIV.
- Patients with sickle-cell anemia or thalassemia major.
- History of any one or more of the following cardiovascular conditions within the past
6 months:
- Cardiac angioplasty or stenting
- Myocardial infarction
- Unstable angina
- Coronary artery bypass graft surgery
- Symptomatic peripheral vascular disease
- History of Class III or IV congestive heart failure, as defined by the New York
Heart Association Classification of Congestive Heart Failure
- History of cerebrovascular accident including transient ischemic attack (TIA),
pulmonary embolism or untreated deep venous thrombosis (DVT) within the past 6
months.
- Any serious and/or unstable pre-existing medical, psychiatric, or other condition that
could interfere with subject's safety, provision of informed consent, or compliance to
study procedures
- Concurrent investigational therapy given to treat cancer or concurrent participation
in another clinical trial involving anti-cancer investigational drug.
- Administration of an investigational drug within 30 days or 5 half-lives, whichever is
longer, preceding the first dose of study treatment.
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