Metastatic Pancreatic Ductal Adenocarcinoma Clinical Trial
Official title:
A Phase 2 Trial to Evaluate the Safety and Antitumor Activity of Pembrolizumab and OLApaRib (POLAR) Maintenance for Patients With Metastatic Pancreatic Ductal Adenocarcinoma and Homologous Recombination Deficiency and/or Exceptional Treatment Response to Platinum-Based Therapy
The study researchers think that combining the drugs pembrolizumab and olaparib (POLAR) may help people with this disease because pembrolizumab activates the immune system to fight cancer, and olaparib destroys cancer cells by preventing them from repairing damage to the genetic information that helps them survive and grow. The study researchers are doing this study to find out whether combining these drugs may be a more effective treatment for this cancer than taking olaparib alone.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT04935359 -
Study of Efficacy and Safety of NIS793 in Combination With Standard of Care (SOC) Chemotherapy in First-line Metastatic Pancreatic Ductal Adenocarcinoma (mPDAC) - daNIS-2
|
Phase 3 | |
| Active, not recruiting |
NCT05095064 -
Retrospective Study on the Efficacy and Tolerability of Liposomal Irinotecan
|
||
| Active, not recruiting |
NCT05039177 -
A Study of ERAS-007 in Patients With Advanced Gastrointestinal Malignancies
|
Phase 1/Phase 2 | |
| Recruiting |
NCT04888312 -
Safety and Efficacy of Mitazalimab in Combination With Chemotherapy in Pancreatic Cancer Patients
|
Phase 1/Phase 2 | |
| Terminated |
NCT04390763 -
Study of Efficacy and Safety of NIS793 (With and Without Spartalizumab) in Combination With SOC Chemotherapy in First-line Metastatic Pancreatic Ductal Adenocarcinoma (mPDAC)
|
Phase 2 | |
| Not yet recruiting |
NCT06206876 -
FL118 for Treating Patients With Advanced Pancreatic Ductal Adenocarcinoma
|
Phase 1 | |
| Recruiting |
NCT05642962 -
Pancrelipase in People With Pancreatic Ductal Adenocarcinoma (PDAC)
|
Phase 1/Phase 2 | |
| Completed |
NCT02501902 -
Dose-Escalation Study Of Palbociclib + Nab-Paclitaxel In mPDAC
|
Phase 1 | |
| Active, not recruiting |
NCT04581343 -
A Phase 1B Study of Canakinumab, Spartalizumab, Nab-paclitaxel, and Gemcitabine in Metastatic PC Patients
|
Phase 1 | |
| Completed |
NCT02558894 -
Phase II Study of MEDI4736 Monotherapy or in Combinations With Tremelimumab in Metastatic Pancreatic Ductal Carcinoma
|
Phase 2 | |
| Terminated |
NCT02732938 -
Ph1b/2 Study of PF-04136309 in Combination With Gem/Nab-P in First-line Metastatic Pancreatic Patients
|
Phase 2 | |
| Recruiting |
NCT05472259 -
A Study Evaluating the Efficacy of 5-FU + NALIRI and 5-FU + NALIRINOX for PDAC (NALPAC)
|
Phase 2 | |
| Recruiting |
NCT06445062 -
Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors
|
Phase 1/Phase 2 | |
| Recruiting |
NCT02600949 -
Personalized Peptide Vaccine in Treating Patients With Advanced Pancreatic Cancer or Colorectal Cancer
|
Phase 1 | |
| Recruiting |
NCT05630183 -
A Study of Botensilimab in Participants With Metastatic Pancreatic Cancer
|
Phase 2 | |
| Completed |
NCT02583477 -
Phase Ib/II Study of MEDI4736 Evaluated in Different Combinations in Metastatic Pancreatic Ductal Carcinoma
|
Phase 1/Phase 2 | |
| Terminated |
NCT04329949 -
Study of Relacorilant in Combination With Nab-Paclitaxel in Patients With Metastatic Pancreatic Ductal Adenocarcinoma
|
Phase 3 | |
| Terminated |
NCT02101021 -
Gemcitabine and Nab-paclitaxel Combined With Momelotinib in Participants With Previously Untreated Metastatic Pancreatic Ductal Adenocarcinoma
|
Phase 3 | |
| Suspended |
NCT05685602 -
CA-4948 Added to Standard Chemotherapy to Treat Metastatic or Unresectable Pancreatic Cancer
|
Phase 1 | |
| Not yet recruiting |
NCT06398587 -
Onvansertib in Combination With Gemcitabine and Nab-paclitaxel for the Treatment of Patients With Locally-advanced, Unresectable, or Metastatic Pancreatic Ductal Adenocarcinoma
|
Phase 2 |