Metastatic Colorectal Cancer Clinical Trial
Official title:
A Prospective Angiogenic Imaging Study With DCE-MRI and DCE-USI in Patients With Colorectal Cancer and Liver Metastases Receiving Sunitinib in Addition to 5-FU, Folinic Acid and Irinotecan (FOLFIRI) as 1st Line Therapy
This is an open label single arm prospective multicenter Phase II study in around 20
patients. The primary objective of this study is to evaluate whether the addition of
sunitinib to FOLFIRI results in a significant reduction of tumor vessel permeability (TVP)
and blood flow (BF) measured by DCE-MRI and DCE-USI, measured on liver metastases.
Secondary objectives are antitumor response, time to progression (TTP), effect on
pharmacokinetics of sunitinib and biomarkers (VEGF und soluble VEGF-receptor) and
drug/treatment safety.
n/a
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