Metastatic Cancer Clinical Trial
Official title:
In Vitro Functional Modulation of Monocyte-derived Dendritic Cells of Patients With Cancer by Peptides
The purpose of this study is to evaluate in vitro the potential of peptides, to modify, phenotypically and functionally, the monocyte-derived dendritic cells of patients with metastatic cancer.
The DCs will be generated in vitro from peripheral blood mononuclear cells (PBMCs) which
will be obtained from 30 ml of peripheral blood collected from each patient with metastatic
cancer by venipuncture in heparin tubes.
The cellular viability, the expression of maturation biomarkers and the presence of several
cytokines will be evaluated by flow cytometric assays after the culture period of DCs
exposed to the peptides.
An interim analysis is programmed with the first 10 patients. If an effect is demonstrated
the study will include an additional number of subjects sufficient to ensure adequate
comparison with other commercially available peptides.
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Observational Model: Case-Only, Time Perspective: Prospective
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