Metabolomics Clinical Trial
Official title:
ET1 Concentration, Metabolic Pathway Activation, and Pulmonary Blood Flow in Infants Undergoing Superior Cavo-Pulmonary Anastomosis
This is a novel preliminary study of biomarkers of pathologic pre-operative pulmonary vascular development, elevated pre-operative Pulmonary Vascular Resistance Index (PVRi), and complications associated with decreased post-operative pulmonary blood flow in single ventricle patients undergoing superior cavo-pulmonary anastomosis (SCPA). The study will utilize a combined targeted and untargeted approach to both optimize translation of a promising existing biomarker and efficiently identify novel biomarkers and potential therapeutic targets in this population.
Overall Hypothesis: Endothelin-1 (ET1) and associated dysregulation of key metabolic pathways decrease pre-operative pulmonary blood vessel development and increase post-operative pulmonary blood vessel resistance leading to decreased pulmonary blood flow in patients undergoing SCPA. For enrolled patients, collected data will include: - 3 mL blood sample (x2) at pre-SCPA catheterization. - 3 mL blood samples at 2, 24, and 48 hours post-operative. - Urine sample pre-operatively and post-operatively - Collection of otherwise-discarded operative tissue sample from the pulmonary artery. - Collection of clinical data, demographic data, and results of routine, post-operative hemodynamic monitoring. ;
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