The Research of Metabolomics on COPD

Status Completed

Clinical Trial Summary

Targeted metabolomics research was conducted on patients with chronic obstructive pulmonary disease (COPD). The correlation analyst between inflammation-related metabolites and lung function was analyzed by explored the metabolic pathways of inflammation-related omega-6 and omega-3 and combining them with lung function.

Clinical Trial Description

Based on the global initiative for chronic obstructive pulmonary disease, the 80 confirmed stable COPD patients with mild-to-moderate were involved, 80 COPD patients with severe and very severe, and age, sex, all matching 40 cases without lung disease. The participants information was collected. Whole blood and pulmonary function were examined at three time points: admission, six months and one year, at the same time, targeted metabolomic analysis method are applied to detect serum metabolites, According to the access to assess the different severity of COPD in the stable period and the level of metabolites in different admission periods. After that, correlation analysis was conducted with pulmonary function indicators and other clinical indicators to observe the research value of inflammation-related metabolites in the development of COPD. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04042519
Study type	Observational
Source	Guangzhou Institute of Respiratory Disease
Contact
Status	Completed
Phase
Start date	October 1, 2016
Completion date	July 5, 2019

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The Research of Metabolomics on COPD — COPD

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms