Effects of Probiotic and HIIT in Obese Women

Metabolism Clinical Trial

Official title:

Effects of Probiotic With HIIT on Cardiorespiratory Endurance and Metabolism in Middle-Aged Obese Women

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT06285578
• Other study ID #: MOST 107-2410-H-277-003
• Status: Completed
• Phase: N/A
• Start date: October 1, 2018
• Est. completion date: March 1, 2019

Study information

• Verified date: February 2024
• Source: University of Taipei
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The aim of this study is to investigate whether there are the additive effects when implementing both high-intensity interval training (HIIT) and probiotics simultaneously on improving cardiorespiratory endurance and metabolism in middle-aged women.

Description:

High-intensity interval training (HIIT) is a time-efficiency exercise mode that has been shown to reduce body fat, fasting blood insulin levels, arterial stiffness, and aerobic capacity, helping to prevent and improve chronic diseases. Probiotics, on the other hand, have been found to have similar effects, including improving insulin sensitivity and endurance exercise performance, as well as reducing body fat. However, the additive effects of HIIT combined with probiotic supplements are unclear. In addition, on average, the life expectancy of women is longer than that of men. Middle-aged women are at high-risk for obesity and metabolic-related problems that threaten their long-term health. Therefore, whether the combination of HIIT and probiotics can be utilized to enhance the wellness of middle-aged women is the objective of this study.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 47
• Est. completion date: March 1, 2019
• Est. primary completion date: January 31, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 35 Years to 55 Years

Eligibility

Inclusion Criteria:

• Female
• Age between 35-55 years old
• Total body fat percentage greater than 30%

Exclusion Criteria:

• Male
• Participants who were taking probiotics supplementation or antibiotics
• Percentage of total body fat less than 30%

Related Conditions & MeSH terms

• Anthropometry
• Cardiorespiratory Fitness
• Metabolism

Intervention

Dietary Supplement:
• Probiotics supplementation
Probiotics, Lactiplantibacillus plantarum TWK10, are packaged in powder form. Each participant consume one packet every day on a fasting status for 8 weeks.

Behavioral:
• HIIT training
HIIT training is conduct at the intensity of 85-90% VO2max for 2 minutes with 1-minute inactive resting interval, repeating for 7 times. 3 sessions per week for 8 weeks.

Dietary Supplement:
• Placebo supplementation
Yeast powder replaces probiotics in each packet. Each participant consume one packet every day on a fasting status for 8 weeks.

Locations

Country	Name	City	State
Taiwan	University of Taipei	Taipei

Sponsors (1)

Lead Sponsor	Collaborator
University of Taipei

Country where clinical trial is conducted

Taiwan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Height	Height in centimeters	8 weeks
Primary	Body weight	Weight in kilograms	8 weeks
Primary	Body mass index (BMI)	Calculated by: weight (kg)/ height (m^2)	8 weeks
Primary	Body fat percentage	Body fat percentage (%) is measured with Dual-energy X-ray absorptiometry (DEXA)	8 weeks
Primary	Waist circumference	Waist circumference in centimeters	8 weeks
Primary	Hip circumference	Hip circumference in centimeters	8 weeks
Primary	Maximum oxygen uptake (VO2max)	VO2max in ml/min/kg	8 weeks
Primary	Time to exhaustion (TTE)	TTE in seconds	8 weeks
Primary	Running economy (RE)	RE in ml/kg/km	8 weeks
Primary	Fasting blood glucose (FBG)	FBG in mg/dL	8 weeks
Primary	Total cholesterol (TC)	TC in mg/dL	8 weeks
Primary	Triglyceride (TG)	TG in mg/dL	8 weeks
Primary	High-density lipoprotein cholesterol (HDL-C)	HDL-C in mg/dL	8 weeks
Primary	Low-density lipoprotein cholesterol (LDL-C)	LDL-C in mg/dL	8 weeks
Secondary	Muscle mass	Muscle mass in kilograms is measured with DEXA	8 weeks
Secondary	Fat mass	Fat mass in kilograms is measured with DEXA	8 weeks
Secondary	Bone mineral density (BMD)	BMD in g/cm^2 is measured with DEXA	8 weeks
Secondary	Caloric intake	Caloric intake in kcal/day	8 weeks