Metabolism Clinical Trial
Official title:
Lactate Metabolism in Patientens With Hyperlactatemia-associated Metabolic Acidosis
NCT number | NCT05582824 |
Other study ID # | LacMeta |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | September 15, 2022 |
Est. completion date | January 2023 |
Investigating lactate metabolism in critically ill patients whom are hypoperfused by preforming metabolomics via liquid chromatography-mass spectrometry.
Status | Recruiting |
Enrollment | 20 |
Est. completion date | January 2023 |
Est. primary completion date | November 2022 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Diagnosed with sepsis/septic shock or severe heart failure. - Clinical and paraclinical signs of hypoperfusion in relation to abovementioned diagnosis. - Metabolic acidosis with s-lactate equal-to-or-above 4 mmol/l. - Incapacitated Exclusion Criteria: - Only regional hypoperfusion such as a leg. - Receiving intravenous lactate as part of treatment. - Going in to dialysis. The exclusion is only during dialysis treatment. |
Country | Name | City | State |
---|---|---|---|
Denmark | Hvidovre University Hospital | Hvidovre | Hovedstaden |
Lead Sponsor | Collaborator |
---|---|
University of Copenhagen | Hvidovre University Hospital |
Denmark,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Laktate levels in blood | Levels of lactate in the blood in relation to the key metabolites (secondary outcomes). Patients included will be testet daily during admission to intensive care whilst lactate is above 2 mmol/l and one more day while laktat is below. | Daily testing. Average time frame for the paticipants are 3 days (ranging from 1-10 days). | |
Secondary | Metabolomics using High Pressure Liquid Cromotografy (HPLC) and Mass Spectrometry (MS) | Frozen samples collectet during inclusion of patients are analyzed using HPLC and MS which yields results that can later be examined. These results indicate which metabolites are related to, and derived from, lactate. Analasys of blood and urine samples will be done at two seperate days. | Two seperate days. One in december 2022 and one in approximately february 2023 (when all patientens are included and all samples are collected). | |
Secondary | Mortality | Whether or not the patient survived the illness that coursed the admission to the ICU and hospital. | Admission time ranges up to 6 months. | |
Secondary | Pyruvate and hydroxybuterate concentration in blood and urine | Concentration of pyruvate and hydroxybutyrate from blood- and urinsamples are analysed by assays kits on the same occation as metabolomics (HPLC and MS) | Two seperate days. One in december 2022 and one in approximately february 2023 (when all patientens are included and all samples are collected). | |
Secondary | Near-infrared spectroscopy (NIRS) | In this case, NIRS consists of two electrodes placed above the eyebrow and on the shoulder. Near-infrared light is sent out by the electrodes to meassure the collour for the blood. Thereby providing information about the oxygen saturation of haemoglobin within the microcirculation. | Daily testing. Average time frame for the paticipants are 3 days (ranging from 1-10 days). | |
Secondary | Peripheral perfusion index (PPI) | PPI is a small clamp around the finger which, like NIRS, uses lightwaves. It measures the ratio of the pulsing blood to non-pulsing blood flow in your finger and is used to indicate the strength of blood flow to your finger. Thereby estimating the microcirculation of the patients. | Daily testing. Average time frame for the paticipants are 3 days (ranging from 1-10 days). |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT00070577 -
Influence of Age and Sex on Alcohol Metabolism and Acute Responses
|
N/A | |
Active, not recruiting |
NCT05488574 -
Effects of Novel Breathing Behavior Modification Yoga Positioning Integrated Program on Weight Loss
|
N/A | |
Recruiting |
NCT05443347 -
Activity, Adiposity, and Appetite in Adolescents 2 Intervention
|
N/A | |
Completed |
NCT05020808 -
The Effect of a Plant Protein Isolate on Muscle Protein Synthesis in Humans at Rest and After Resistance Exercise
|
N/A | |
Recruiting |
NCT06082726 -
The Systemic Concentration of Short-Chain Fatty Acids After Delivery in the Small and Large Intestine of Healthy Volunteers
|
N/A | |
Completed |
NCT04144426 -
Meal Schedule Effects on Circadian Energy Balance in Adults
|
N/A | |
Completed |
NCT03424395 -
Personalized Dietary Program and Markers of Wellness
|
N/A | |
Completed |
NCT02441296 -
Carbohydrate and Metabolism: a Pilot Study
|
N/A | |
Completed |
NCT00176085 -
Pharmacokinetics of THCCOOH and Its Acyl-glucuronide After Intravenous Administration of THCCOOH
|
Phase 1 | |
Completed |
NCT00245986 -
Effect of Genetics on Metabolism of Efavirenz
|
Phase 4 | |
Completed |
NCT04025346 -
To Evaluate the Efficacy of Capsimax on Metabolic Rate
|
N/A | |
Completed |
NCT04078646 -
Influence of Proteins on the Bioavailability of Carotenoids
|
N/A | |
Active, not recruiting |
NCT06033898 -
Inactivity Duration on Lipid Metabolism
|
N/A | |
Active, not recruiting |
NCT06250270 -
Effects of Casein Protein on Metabolism When Taken Prior to Sleep and in the Morning
|
Early Phase 1 | |
Completed |
NCT06285578 -
Effects of Probiotic and HIIT in Obese Women
|
N/A | |
Completed |
NCT04255368 -
Choline Source, Gut Microbiota and Trimethylamine-N-oxide Response
|
N/A | |
Recruiting |
NCT06360796 -
Study of Pharmacokinetics and Metabolism on [(14)C]ADC189
|
Phase 1 | |
Recruiting |
NCT02005003 -
Cognitive and Metabolic Effects of a Probiotic Supplement
|
N/A | |
Completed |
NCT03146728 -
Finding the Optimal Voluntary Exercise Parameters for Those Living With Quadriplegia
|
N/A | |
Completed |
NCT00692510 -
Drug Interaction Study Between AZD3480 and Cytochrome P450
|
Phase 1 |