Metabolism Clinical Trial
Official title:
The Physiological Effects of Capsaicinoid Ingestion on Human Metabolism and Exercise Performance
Capsaicinoids (the active ingredient in hot peppers) have been shown to cause a moderate increase in energy expenditure (50 kcal/day) as well as reductions in appetite, energy intake, and (visceral) adiposity. As such, there is considerable interest in capsaicinoid for weight loss supplements. Of particular interest are the recent findings that free-fatty acids in the blood are elevated 2-2.5hrs post ingestion, yet changes in typical cardiovascular or sympathetic nervous tone indicators (heart rate, blood pressure) were unaffected, suggesting some of the negative consequences of other stimulants may be avoided. At present, however, more in depth investigations of the effects on endothelial function, vascular autonomic tone and inflammation are lacking. The investigators seek to understand the effect of 3 months capsaicinoid ingestion on alterations in body composition, traditional cardiovascular risk factors and cardiovascular function Hypotheses: 1) Continued use of capsaicinoids will alter resting metabolism substrate use, which will result in moderate (but clinically meaningful) alterations in body composition manifested as a decrease in adiposity. 2) Blood lipids will be unaffected by capsaicinoid use, as will brachial blood pressure. 3) Levels of systemic inflammation may increase slightly, and this could have an effect on vascular reactivity to hyperemic flow or baseline vascular tone. However, previous research suggests that these alterations will not be manifested in autonomic nervous tone assessed by changes in heart rate variability.
Project abandoned ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT00070577 -
Influence of Age and Sex on Alcohol Metabolism and Acute Responses
|
N/A | |
| Active, not recruiting |
NCT05488574 -
Effects of Novel Breathing Behavior Modification Yoga Positioning Integrated Program on Weight Loss
|
N/A | |
| Recruiting |
NCT05582824 -
Lactate Metabolism in the Hypoperfused Critically Ill
|
||
| Recruiting |
NCT05443347 -
Activity, Adiposity, and Appetite in Adolescents 2 Intervention
|
N/A | |
| Completed |
NCT05020808 -
The Effect of a Plant Protein Isolate on Muscle Protein Synthesis in Humans at Rest and After Resistance Exercise
|
N/A | |
| Recruiting |
NCT06082726 -
The Systemic Concentration of Short-Chain Fatty Acids After Delivery in the Small and Large Intestine of Healthy Volunteers
|
N/A | |
| Completed |
NCT04144426 -
Meal Schedule Effects on Circadian Energy Balance in Adults
|
N/A | |
| Completed |
NCT03424395 -
Personalized Dietary Program and Markers of Wellness
|
N/A | |
| Completed |
NCT02441296 -
Carbohydrate and Metabolism: a Pilot Study
|
N/A | |
| Completed |
NCT00176085 -
Pharmacokinetics of THCCOOH and Its Acyl-glucuronide After Intravenous Administration of THCCOOH
|
Phase 1 | |
| Completed |
NCT00245986 -
Effect of Genetics on Metabolism of Efavirenz
|
Phase 4 | |
| Completed |
NCT04025346 -
To Evaluate the Efficacy of Capsimax on Metabolic Rate
|
N/A | |
| Completed |
NCT04078646 -
Influence of Proteins on the Bioavailability of Carotenoids
|
N/A | |
| Active, not recruiting |
NCT06033898 -
Inactivity Duration on Lipid Metabolism
|
N/A | |
| Active, not recruiting |
NCT06250270 -
Effects of Casein Protein on Metabolism When Taken Prior to Sleep and in the Morning
|
Early Phase 1 | |
| Completed |
NCT06285578 -
Effects of Probiotic and HIIT in Obese Women
|
N/A | |
| Completed |
NCT04255368 -
Choline Source, Gut Microbiota and Trimethylamine-N-oxide Response
|
N/A | |
| Recruiting |
NCT06360796 -
Study of Pharmacokinetics and Metabolism on [(14)C]ADC189
|
Phase 1 | |
| Recruiting |
NCT02005003 -
Cognitive and Metabolic Effects of a Probiotic Supplement
|
N/A | |
| Completed |
NCT03146728 -
Finding the Optimal Voluntary Exercise Parameters for Those Living With Quadriplegia
|
N/A |