Effects of Fructose and Exercise on Hepatic Lipid Metabolism

Metabolism Clinical Trial

— FRUCTEXER  

Official title:

Effects of a Weight Maintenance, High Fructose Diet and of Exercise on Hepatic Lipid Metabolism

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01121003
• Other study ID #: Protocole 220/09
• Status: Completed
• Phase: N/A
• First received: May 6, 2010
• Last updated: October 18, 2011
• Start date: May 2010
• Est. completion date: October 2011

Study information

• Verified date: October 2011
• Source: University of Lausanne
• Contact: n/a
• Is FDA regulated: No
• Health authority: Switzerland: Ethikkommission
• Study type: Interventional

Clinical Trial Summary

8 healthy male volunteers will be studied each on 3 occasions, ie

• after 4 days on a weight maintenance diet containing 5% simple sugars + low physical activity

• after 4 days on a weight maintenance diet containing 30% fructose + low physical activity

• after 4 days on a weight maintenance diet containing 30% fructose + high physical activity At the end of each of these 3 periods, fructose induced hepatic de novo lipogenesis (13C palmitate synthesis in response to ingestion of a 13C fructose load) and plasma VLDL-triglyceride kinetics (measured with a bolus of 2H-labeled glycerol) will be measured

Recruitment information / eligibility

• Status: Completed
• Enrollment: 8
• Est. completion date: October 2011
• Est. primary completion date: October 2011
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 30 Years

Eligibility

Inclusion Criteria:

• age between 18 and 30 years

• males

• BMI between 19 and 25

• low to moderate physical activity (< 3 sessions/week)

Exclusion Criteria:

• smoking

• consumption of alcohol>50g/week

• consumption of drugs or illicit substances

• food allergies

Study Design

Allocation: Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Metabolism

Intervention

Behavioral:
• weight maintenance, low sugar diet

• weight maintenance, high fructose diet

• weight maintenance, high fructose diet+ exercise

Locations

Country	Name	City	State
Switzerland	Centre Hospitalier Universitaire Vaudois	Lausanne	VD

Sponsors (2)

Lead Sponsor	Collaborator
University of Lausanne	Centre Hospitalier Universitaire Vaudois

Country where clinical trial is conducted

Switzerland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Hepatic de novo lipogenesis	Measurement of 13C VLDL palmitate after ingestion of 13C fructose	after 4 days on controlled diet+exercise	No
Secondary	Plasma VLDL-triglyceride kinetics	Modelling of 2H5-glycerol incorporation in VLDL afetr administration of a bolus of 2H5 glycerol	after 4 days on controlled diet+exercise	No