Critical Periods of Exercise

Metabolism Clinical Trial

Official title:

Critical Periods of Exercise

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01041820
• Other study ID #: F090904001
• Status: Completed
• Phase: N/A
• Start date: December 2009
• Est. completion date: June 2011

Study information

• Verified date: November 2019
• Source: University of Alabama at Birmingham
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Early childhood (~3-7 years of age) is an important window for determining body composition trajectory and may be a critical period for the development of tissue partitioning patterns that influence obesity risk. As adiposity accelerates during this critical period, deposition/ preservation of fat stores may be sustained at the 'expense' of other tissues; i.e. energy homeostasis may be inherently biased toward fat gain. The type and amount of tissue mass accrued in early childhood has implications for metabolic profile, glucose/insulin homeostasis, hormone profile and resting energy expenditure.

The interplay between fat and bone deposition represents a physiologic trait enabling the body to choose between shuttling 'energy' towards accrual of a particular tissue. Plausibly the phenotype underlying obesity and diabetes risk may be determined by the differentiation of cell type (adipocyte, osteocyte, etc.) during this early stage of growth and development. In vitro studies demonstrate transdifferentiation under the influence of specific external stimuli, which can switch phenotypes toward other cell lineages. Further, rodent models have demonstrated that exposure to stimuli (exercise) early in life may prevent excess fat mass accrual in adulthood, even when the stimulus is later removed (animals are no longer exercising). Children's early experiences (engagement in physical activity vs. sedentary behavior) may 'environmentally induce' alterations in body composition and predispose individuals to obesity throughout life.

Aim 1. To examine the associations between body composition via DXA and objectively-measured physical activity/inactivity.

1. Hypothesis 1.1: There is a positive association between physical activity and bone mass.

2. Hypothesis 1.2: There is a positive association between sedentary behavior and total fat mass.

Aim2. To examine the associations between adipose tissue distribution via MRI and objectively-measured physical activity/inactivity.

3. Hypothesis 2.1: There is an inverse association between physical activity and bone marrow adipose tissue.

4. Hypothesis 2.2: There is a positive association between sedentary behavior and bone marrow adipose tissue.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 20
• Est. completion date: June 2011
• Est. primary completion date: December 2010
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 3 Years to 7 Years

Eligibility

Inclusion Criteria:

• children aged 3 to 7 years

• healthy, not under the care of a doctor

• not taking medications known to alter body composition or metabolism

Related Conditions & MeSH terms

• Metabolism

Intervention

Behavioral:
• Exercise
Children will be exposed to a 10-week exercise intervention

Locations

Country	Name	City	State
United States	Family Care Center	Birmingham	Alabama
United States	University of Alabama at Birmingham	Birmingham	Alabama

Sponsors (1)

Lead Sponsor	Collaborator
University of Alabama at Birmingham

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Association between exercise and bone marrow adipose tissue in children 3-7 years		10 weeks of exercise