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Testing the Adipose Expandability Hypothesis In Vivo During Overfeeding — EAT 2  

Metabolic Syndrome Clinical Trial

Official title:
Testing the Adipose Expandability Hypothesis In Vivo During Overfeeding

Clinical Trial Summary

Adipose, or fat, tissue is a plastic organ that retains the ability to expand and store excess calories during positive energy balance in humans. The capacity of subcutaneous (subQ) adipose tissue to expand and remodel is an important determinant of obesity-related health complications, and impaired expansion of subQ fat tissue is thought to contribute to the risk of diseases such as the Metabolic Syndrome (MetS) and type 2 diabetes mellitus (T2D). The objectives of the study are to evaluate the changes and mechanisms of (subQ) adipose tissue expandability that occur as a result of short-term weight gain and to investigate the effects on cardio-metabolic health outcomes. Findings from this study will provide new insight into the dynamics of adipose expansion and remodeling during changes in energy balance and how this may impact future fat tissue function and metabolic health.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04583514
Study type Interventional
Source Pennington Biomedical Research Center
Contact Ursula White, Ph.D.
Phone 225-763-2656
Email ursula.white@pbrc.edu
Status Recruiting
Phase N/A
Start date September 15, 2020
Completion date December 31, 2025
View Details
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