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Effects of Exercise and GLP-1 Agonism on Muscle Microvascular Perfusion and Insulin Action in Adults With Metabolic Syndrome — ZQL008  

Metabolic Syndrome Clinical Trial

Official title:
Effects of Exercise and GLP-1 Agonism on Muscle Microvascular Perfusion and Insulin Action in Adults With Metabolic Syndrome

Clinical Trial Summary

The primary objective of this study is to examine whether exercise training alone, liraglutide treatment alone or exercise training plus liraglutide treatment increases cardiac and skeletal muscle microvascular blood volume, improves vascular function of the conduit vessels, and enhances insulin's metabolic action in humans with Metabolic Syndrome. Subjects will be randomized to one of the 4 groups: control, exercise training, liraglutide treatment, and exercise + liraglutide. They will be studied at the baseline and then after 24 weeks of intervention.

Clinical Trial Description

Our hypothesis is that sustained activation of the GLP-1 receptor with Liraglutide and exercise training each will enhance microvascular insulin responses and angiogenesis in both cardiac and skeletal muscle to increase muscle insulin delivery and action and the combination of both is more effective than either alone in adults with metabolic syndrome. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04575844
Study type Interventional
Source University of Virginia
Contact Lee Hartline, MEd
Phone 434-924-5247
Email lmh9d@virginia.edu
Status Recruiting
Phase Phase 4
Start date November 1, 2020
Completion date April 1, 2025
View Details
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