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Exercise Dose and Metformin for Vascular Health in Adults With Metabolic Syndrome

Metabolic Syndrome Clinical Trial

Official title:
Exercise Dose and Metformin for Vascular Health in Adults With Metabolic Syndrome

Clinical Trial Summary

Health organizations recommend exercise in an intensity based manner to promote cardiovascular adaptation and prevent disease. Metformin is a common anti-diabetes medication that reduces future type 2 diabetes and cardiovascular disease (CVD) risk. However, the optimal dose of exercise to be combined with metformin for vascular health remains unknown. The purpose of this study is to evaluate whether combining high or low intensity exercise with metformin has the potential to outperform either exercise intensity alone on blood flow across the arterial tree as well as impact insulin action in individuals with metabolic syndrome. Identification of such outcomes will indicate 1) whether and how metformin should be combined with physical activity for CVD prevention, 2) provide the first indication of whether exercise intensity reduces CVD risk via multi-level vasculature function vs. metabolic insulin action, and 3) provide a rational early treatment for people with metabolic syndrome to prevent/treat type 2 diabetes and CVD.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03355469
Study type Interventional
Source Rutgers, The State University of New Jersey
Contact Applied Metabolism and Physiology Lab
Phone 434-243-8677
Email slm4ps@virginia.edu
Status Recruiting
Phase Phase 2/Phase 3
Start date August 7, 2017
Completion date January 30, 2025
View Details
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