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Simvastatin With or Without Ezetimibe and Atherothrombotic Biomarker Assessment

Metabolic Syndrome Clinical Trial

Official title:
The Effects of Ezetimibe/Simvastatin Versus Simvastatin Alone on Platelet and Inflammatory Biomarkers in Patients With the Metabolic Syndrome

Clinical Trial Summary

To determine whether the combination of ezetimibe and simvastatin improves biomarkers of atherothrombosis compared to simvastatin alone in patients with the metabolic syndrome.

Clinical Trial Description

1. To assess the ex vivo effects of ezetimibe/simvastatin (E/S) (Vytorin 10/40mg) and simvastatin (S) (Zocor 40mg) on platelet and inflammation biomarkers in patients with documented metabolic syndrome.

2. To compare platelet-related effects including PAR-1 receptor inhibition of E/S with those of the established anti-platelet agents including aspirin, clopidogrel, intravenous and oral glycoprotein IIb/IIIa inhibitors.

3. To determine whether the addition of ezetimibe will yield extra protection beyond lipid modulation in the reduction of inflammation and platelet activation. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00819403
Study type Interventional
Source University of Maryland, Baltimore
Contact
Status Completed
Phase Phase 4
Start date January 2009
Completion date November 2011
View Details
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